Neurophysins as Markers of Vasopressin and Oxytocin Release
A Study in Carcinoma of the LungLegros J.J. · Geenen V. · Carveli T. · Martens H. · Andre M. · Corhay J.L. · Radermecker M. · Zangerle P.F. · Sassolas G. · Gharib C. · Vantyghen M. · Lefebvre J.
aService d’Endocrinologie, Unité de Neuroendocrinologie, et bService de Pneumologie, CHU, Université de Liège; cService de Médecine Interne-Rhumatologie, Centre Hospitalier de Ste-Ode, Baconfoy, Belgique; dCentre de Médecine Nucléaire, Hôpital Neurocardiologique, et eΗôpitaux de Lyon, Université Claude-Bernard, Faculté de Médecine Grange-Blanche, Lyon; fDépartement d’Endocrinologie, Métabolique, Nutrition et Reproduction, USNA, Lille, France
Vasopressin-neurophysin (hNpI), oxytocin-neurophysin (hNpII) and blood osmolality were assayed before any treatment in basal conditions in 35 patients suffering from lung carcinoma (20 oat cell, 6 undifferentiated and 9 well-differentiated epidermoid cell carcinomas). Plasma vasopressin (antidiuretic hormone, ADH) was also assayed in 7 of the 20 patients suffering from oat cell carcinoma. We found a close correlation (r=0.98) between plasma ADH and hNpI levels in the 7 patients. Further, hNpI was elevated in 13 out of the 20 oat cell carcinoma patients and in none of the epidermoid-cell carcinoma group; however searching for an abnormality of ADH secretion as reflected by a detectable plasma hNpI level together with subnormal plasma osmolality revealed 2 additional positive results in the oat cell carcinoma group, and 2 out of the 6 in the undifferentiated-cell carcinoma group. hNpII was increased together with an increase in hNpI in 6 oat cell carcinoma patients; it was specifically increased without hNpI increment in 2 additional oat cell carcinoma patients and in 2 patients of the undifferentiated-cell carcinoma group (different from the 2 positive for the hNpI-osmolality ratio). hNpI and hNpII were normal in the majority of undifferentiated and all of the differentiated epidermoid-cell carcinoma group. Hence, our results show that simultaneous measurements of hNpI, hNpII, and blood osmolality could detect abnormalities in 17 out of 20 oat cell carcinoma patients, in 4 of the 9 undifferentiated-cell carcinoma patients, but in none of the differentiated epidermoid-cell carcinoma patients, suggesting that the neurophysin assay can be used for the early detection of oat cell- and possibly other neuroendocrine-derived carcinomas.
J.J. Legros, MD, Service d’Endocrinologie, Unité de Neuroendocrinologie, CHU-B23, Université de Liège, J3-4000 Liège (Belgium)
Published online: December 02, 2008
Number of Print Pages : 5
Hormone Research (From Developmental Endocrinology to Clinical Research)
Vol. 34, No. 3-4, Year 1990 (Cover Date: 1990)
Journal Editor: Czernichow P. (Paris)
ISSN: 0301–0163 (Print), eISSN: 1423–0046 (Online)
For additional information: http://www.karger.com/HRE