Pharmacology and Treatment
Absence of Efficacy of Oral Isotretinoin in Hidradenitis Suppurativa: A Retrospective Study Based on Patients’ Outcome AssessmentSoria A.a · Canoui-Poitrine F.b, d · Wolkenstein P.a · Poli F.a · Gabison G.a · Pouget F.a · Viallette C.c · Revuz J.a
aService de Dermatologie, bService de Santé Publique et cUnité de Recherche Clinique, Groupe Hospitalier Henri Mondor et Albert Chenevier, Assistance Publique – Hôpitaux de Paris, Université Paris 12, Créteil, et dPôle d‘Information Médicale Evaluation Recherche des Hospices Civils de Lyon, Université Lyon 1, Lyon, France
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Background: In analogy to acne, oral isotretinoin has been considered in the treatment of hidradenitis suppurativa (HS). Objectives: To assess the efficacy of oral isotretinoin according to patients. Methods: From 1999 to 2006, 358 consecutive HS patients were interviewed and examined. A standardized record of the data was performed for each patient during the first consultation. Patients were questioned regarding the effect of previous treatment with oral isotretinoin: patients had to grade the effect as either ‘improved’, ‘no effect’ or ‘worse’. Results: Fourteen patients (16.1%) declared an improvement, 67 patients (77%) no effect and 6 patients (6.9%) worsening of HS. Conclusion: According to our patients, oral isotretinoin is not effective in the treatment of HS.
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