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Vol. 37, Suppl. 3, 1992
Issue release date: 1992
Section title: Session I: Neuroendocrinology
Horm Res 1992;37:1–10
(DOI:10.1159/000182393)

Steroid Hormones: Effect on Brain Development and Function

McEwen B.S.
Laboratory of Neuroendocrinology, Rockefeller University, New York, USA

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Article / Publication Details

First-Page Preview
Abstract of Session I: Neuroendocrinology

Published online: 12/3/2008

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Hormones secreted by the adrenals, gonads and thyroid play an important role in mediating how the environment shapes the structure and function of the brain during early development, adult life and senescence. Many of these hormone effects occur at the level of gene transcription, via the actions of intracellular hormone receptors which are DNA-binding proteins. Other effects occur at the membrane level via receptors on the cell surface that produce rapid effects on bioelectrical activity and secondary messenger systems. Hormone effects on the brain are classified as organizational, occurring during development; cyclical, occurring during maturity; experiential, depending on the individual experiences; and disorganizational, leading to damage and destruction of neural tissue. Organizational effects, such as occur as a result of testosterone action during sexual differentiation, give rise to group differences; whereas experiential effects, in which hormone secretion is evoked on an individual basis according to personal life events, are responsible for individual differences even between identical twins having the same genetic constitution. Experiential effects, often involving stress and possibly thyroid hormones, may result in adaptation or may lead to disorganization and damage under extreme and deleterious conditions.


  

Author Contacts

B.S. McEwen, MD, Laboratory of Neuroendocrinology, Rockefeller University, 1230 York Avenue, New York, NY (USA)

  

Article Information

Published online: December 03, 2008
Number of Print Pages : 10

  

Publication Details

Hormone Research (From Developmental Endocrinology to Clinical Research)

Vol. 37, No. Suppl. 3, Year 1992 (Cover Date: 1992)

Journal Editor: Czernichow P. (Paris)
ISSN: 0301–0163 (Print), eISSN: 1423–0046 (Online)

For additional information: http://www.karger.com/HRE


Article / Publication Details

First-Page Preview
Abstract of Session I: Neuroendocrinology

Published online: 12/3/2008

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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