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Vol. 39, No. 1-2, 1993
Issue release date: 1993
Section title: Original Paper
Horm Res 1993;39:61–66
(DOI:10.1159/000182697)

Subclinical Hypothyroidism: A Determinant of Polycystic Ovary Syndrome

Ghosh S. · Kabir S.N. · Pakrashi A. · Chatterjee S. · Chakravarty B.
aIndian Institute of Chemical Biology, Reproductive Biology Research Division, Jadavpur; and, bInstitute of Reproductive Medicine, Calcutta, India

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/15/1992
Accepted: 12/11/1992
Published online: 12/3/2008
Issue release date: 1993

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

The present study was an endeavor to explore whether and how hypothyroidism plays a role in the etiology of polycystic ovarian syndrome (PCOS). A composite picture of the hormone profile was assessed in different groups of subjects (control women and hypothyroid women with or without PCOS). Comparative analysis of the results suggests that hypothyroidism is invariably followed by a lowering of sex hormone binding globulin and an increment in the free testosterone level, but further metabolism of testosterone (T) may or may not be directed towards an overproduction of estriol (E3). The factors that dictate the route of T metabolism, and the way by which E3 acts to rescue the ovaries from the development of PCOS under the hypothyroid state are discussed.


  

Author Contacts

Dr. A. Pakrashi, Indian Institute of Chemical Biology, Reproductive Biology Research Division, 4 Raja S.C. Mullick Road, Jadavpur, Calcutta, 700 032 (India)

  

Article Information

Received: September 15, 1992
Accepted: December 11, 1992
Published online: December 03, 2008
Number of Print Pages : 6

  

Publication Details

Hormone Research (From Developmental Endocrinology to Clinical Research)

Vol. 39, No. 1-2, Year 1993 (Cover Date: 1993)

Journal Editor: Czernichow P. (Paris)
ISSN: 0301–0163 (Print), eISSN: 1423–0046 (Online)

For additional information: http://www.karger.com/HRE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/15/1992
Accepted: 12/11/1992
Published online: 12/3/2008
Issue release date: 1993

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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