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Vol. 41, No. 2, 1985
Issue release date: 1985
Section title: Original Paper
Nephron 1985;41:132–140
(DOI:10.1159/000183568)

Calcium Balance in Uremia: Longitudinal Study of Long-Term Survivors

Schuster V.L. · Chesnut, III C.H. · Baylink D.J. · Sherrard D.J.
University of Washington School of Medicine and Veterans Administration Medical Center, Seattle, Wash., and Veterans Administration Medical Center, Tacoma, Wash., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: 1/8/1985
Published online: 12/4/2008

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

Twelve male patients surviving uremia of 9–15 years duration were studied sequentially over a mean period of 9.2 years. Radiographs, bone biopsies, bone mineral mass (BMM) measured by photon absorptiometry, and total body calcium (TBC) determined by in vivo neutron activation analysis (NAA) were used. Pathologic fractures correlated with TBC corrected for height: 4 of 5 patients without fractures had TBC above 80% predicted, whereas 5 of 7 patients with fractures fell below this value. Unlike previous studies, negative calcium balance was seen in 3 patients with prolonged hyperparathyroidism. Though soft tissue calcification occurred in 6 patients, only 1 with massive shoulder calcification had an increase in TBC; this drawback of NAA has been previously overemphasized. Moreover, radial BMM also increased in 2 patients due to soft tissue calcification. When viewed at a single point in time, nearly all patients fell within the wide normal limits of BMM vs TBC. However, 6 patients with variable bone histology studied sequentially over a mean of 8.5 years showed significant preferential loss of radial bone mass compared to TBC. Aluminium retention did not influence calcium balance in these subjects.


  

Author Contacts

Donald J. Sherrard, MD, Veterans Administration Medical Center, 1660 South Columbian Way, Seattle, WA 98108 (USA)

  

Article Information

Accepted: January 8, 1985
Published online: December 04, 2008
Number of Print Pages : 9

  

Publication Details

Nephron

Vol. 41, No. 2, Year 1985 (Cover Date: 1985)

Journal Editor: Fine L.G. (Los Angeles, Calif.)
ISSN: 0028-2766 (Print), eISSN: 1423-0186 (Online)

For additional information: http://www.karger.com/NEF


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: 1/8/1985
Published online: 12/4/2008

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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