Detailed studies of the ontogeny of growth hormone (GH) secretion have shown unequivocally that GH is produced throughout life but secretion declines progressively to about 20% of that in puberty. These changes are accounted for in part by changes in central neuro-endocrine function, nutritional factors and by changes in sex steroid milieu. Mean 24-hour GH concentrations in the normal elderly are frequently below the limit of assay detectability where values are indistinguishable from matched adults with organic GH deficiency. The notion that diminished GH action may account for the undesirable changes in body composition and function in the elderly is supported by beneficial findings of GH treatment in GH-deficient adults. Preliminary results of GH treatment in the normal elderly suggest beneficial effects on body composition but a high incidence of side-effects. Questions addressing cost, benefit, dosage, safety and tolerance need to be critically addressed before GH can be considered for use in the aging.
© 1993 S. Karger AG, Basel
Dr. Ken Ho, Associate Professor of Medicine, Garvan Institute of Medical Research, St. Vincent’s Hospital, Sydney, NSW 2010 (Australia)
Published online: December 05, 2008
Number of Print Pages : 7
Hormone Research (From Developmental Endocrinology to Clinical Research)
Vol. 40, No. 1-3, Year 1993 (Cover Date: 1993)
Journal Editor: Czernichow P. (Paris)
ISSN: 0301-0163 (Print), eISSN: 1423-0046 (Online)
For additional information: http://www.karger.com/HRE
Article / Publication Details
Published online: 12/5/2008
Issue release date: 1993
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: http://www.karger.com/HRP
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