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Vol. 200, No. 4, 2000
Issue release date: 2000
Section title: Case Report
Dermatology 2000;200:331–333
(DOI:10.1159/000018399)

Muir-Torre Syndrome – Treatment with Isotretinoin and Interferon Alpha-2a Can Prevent Tumour Development

Graefe T.a · Wollina U.a · Schulz H.-J.b · Burgdorf W.c
aDepartment of Dermatology and Allergology, Friedrich Schiller University of Jena, bInstitute for Clinical Pathology and Cytology, Eisenach, and cDepartment of Dermatology, Ludwig Maximilians University, Munich, Germany

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Published online: 7/6/2000
Issue release date: 2000

Number of Print Pages: 3
Number of Figures: 2
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Muir-Torre syndrome is a genodermatosis in which multiple internal malignancies are associated with cutaneous sebaceous tumours and kerato-acanthomas. A 57-year-old man presented with multiple sebaceous tumours, kerato-acanthomas, verrucous carcinoma of the nose, renal cell and transitional cell carcinomas of the left kidney, adenoma of the colon and a positive family history of colon carcinoma. He was treated with interferon (IFN-α2a) s.c. 3 × 106 U three times a week along with 50 mg isotretinoin daily as well as topical isotretinoin gel. During a follow-up of 29 months, only 1 sebaceous skin tumour developed and was removed, whereas more than 30 such skin tumours had been surgically removed during the last 3 years. No evidence of internal tumour development or recurrence was found. The combination of IFN with retinoids seems to be of promise to prevent tumour development in Muir-Torre syndrome.

© 2000 S. Karger AG, Basel


  

Author Contacts

U. Wollina
Department of Dermatology, Friedrich Schiller University of Jena
Erfurter Strasse 35
D–07740 Jena (Germany)
Fax +49 3641 93 74 16, E-Mail uwol@derma.uni-jena.de

  

Article Information

Received: Received: December 24, 1999
Accepted: March 2, 2000
Number of Print Pages : 3
Number of Figures : 2, Number of Tables : 0, Number of References : 18

  

Publication Details

Dermatology (International Journal for Clinical and Investigative Dermatology)
Founded as ‘Dermatologische Zeitschrift’ by Oskar Lassar (1893–1907); Continued by Erich Hoffmann (1908–1938), continued as ‘Dermatologica’ (1939–1991), by Wilhelm Lutz (1939–1958), Rudolf Schuppli (1959–1985)
Official Organ of the Swiss Society for Dermatology and Venereology; Official Organ of the Belgian Royal Society for Dermatology and Venereology

Vol. 200, No. 4, Year 2000 (Cover Date: 2000)

Journal Editor: J.-H. Saurat, Geneva.
ISSN: 1018–8665 (print), 1421–9832 (Online)

For additional information: http://www.karger.com/journals/drm


Article / Publication Details

First-Page Preview
Abstract of Case Report

Published online: 7/6/2000
Issue release date: 2000

Number of Print Pages: 3
Number of Figures: 2
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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