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Copy Number Variation and Complex Disease

Copy number variation of Fc gamma receptor genes and disease predisposition

Fanciulli M.a · Vyse T.J.b · Aitman T.J.a, b

Author affiliations

aPhysiological Genomics and Medicine Group and bSection of Molecular Genetics and Rheumatology, MRC Clinical Sciences Centre, Imperial College, London (UK)

Related Articles for ""

Cytogenet Genome Res 123:161–168 (2008)

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Article / Publication Details

First-Page Preview
Abstract of Copy Number Variation and Complex Disease

Accepted: June 20, 2008
Published online: March 11, 2009
Issue release date: March 2009

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Naturally occurring variation in gene copy number is increasingly recognized as a major source of inter-individual differences in phenotype and is an important susceptibility factor for genetically complex diseases. Several studies provide evidence of copy number variation at genes involved in inflammation and immunity highlighting their possible contribution to the inter-individual variation observed in immune responses. This review will explore copy number variation at the Fc gamma receptor cluster and its relevance in the pathogenesis of common human diseases.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Copy Number Variation and Complex Disease

Accepted: June 20, 2008
Published online: March 11, 2009
Issue release date: March 2009

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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