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Vol. 45, Suppl. 1, 1996
Issue release date: 1996
Horm Res 1996;45:55–58
(DOI:10.1159/000184832)
Symposium III: Bone Biology and Growth

Biochemical Markers of Bone Turnover

Crofton P.M.a · Stirling H.F.b · Schönau E.d · Ahmed S.F.b · Wallace W.H.B.c · Wade J.C.b · Magowan R.b · Shrivastava A.b · Lyon A.J.b · Mclntosh N.b · Kelnar C.J.H.b
aDepartment of Paediatric Biochemistry, Royal Hospital for Sick Children, bDepartment of Child Life and Health, University of Edinburgh, and cDepartment of Oncology, Royal Hospital for Sick Children, Edinburgh, UK; dChildren’s Hospital, University of Cologne, Cologne, Germany

Abstract

Three studies to evaluate procollagen type I C-terminal propeptide, type I collagen cross-linked telopeptide and bone alkaline phosphatase (BALP) in the assessment of bone turnover and growth in children are presented. (1) In 50 short normal children treated with placebo or growth hormone, ΔBALP after 3 months of treatment was highly correlated with height velocity response after 1 year (r = 0.67, p < 0.0001). (2) In 12 children with acute lymphoblastic leukaemia, marked changes in collagen peptides, BALP, and lower leg length velocity were seen during the first 6 months of chemotherapy. Suppression occurred during induction and the two intensification phases, with catch-up during the intervening phase (paired t-tests, p < 0.001). (3) Fourteen babies (birthweight < 1,500 g) treated with high-dose dexamethasone for bronchopulmonary dysplasia were compared with 25 non-steroid-treated babies < 1,500 g. Both collagen peptides decreased rapidly and dramatically (mean decreases 41-68%) after dexamethasone was started, accompanied by weight loss and lower leg shrinkage and followed by recovery during steroid weaning.

 goto top of outline Author Contacts

Dr. P.M. Crofton, PhD, Department of Paediatric Biochemistry, Royal Hospital for Sick Children, Sciennes Road, Edinburgh EH9 1LF (UK)


 goto top of outline Article Information

Published online: December 10, 2008
Number of Print Pages : 4


 goto top of outline Publication Details

Hormone Research (From Developmental Endocrinology to Clinical Research)

Vol. 45, No. Suppl. 1, Year 1996 (Cover Date: 1996)

Journal Editor: Czernichow P. (Paris)
ISSN: 0301-0163 (Print), eISSN: 1423-0046 (Online)

For additional information: http://www.karger.com/HRE


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