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Vol. 59, No. 4, 1991
Issue release date: 1991
Section title: Original Paper
Nephron 1991;59:621–625
(DOI:10.1159/000186654)

Assessment of Creatinine Clearance in Healthy Subjects over 65 Years of Age

Nicoll S.R.a · Sainsbury R.a · Bailey R.R.a · King A.c · Frampton C.d · Elliot J.R.a · Turner J.G.c
Departments of aΗealth Care of the Elderly, bNephrology, cNuclear Medicine and dCommunity Health, Princess Margaret Hospital, Christchurch, New Zealand

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: 3/15/1991
Published online: 12/11/2008
Issue release date: 1991

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

Eighteen healthy people over 65 years of age were studied to compare the 99mTC-diethylenetriamine pentaacetic acid (DTPA) clearance, the measured 24-hour creatinine clearance and the assessed creatinine clearance using the Cockcroft and Gault (C-G) formula to measure their glomerular filtration rate. Significant correlations were found between the isotopic method and the measured creatinine clearance (r = 0.71; p < 0.001); the measured creatinine clearance and the C-G formula (r = 0.81; p < 0.001), and the isotopic method and the C-G formula (r = 0.70; p < 0.001). The C-G formula correlated better with both the 99mTc-DTPA clearance and the measured creatinine clearance when the female correction factor was used. This study has shown that in healthy, elderly people, the C-G formula for assessing the creatinine clearance correlated extremely well with the standard clinical tests for measuring the glomerular filtration rate. Whilst the formula has clinical value and allows rapid and accurate assessment of renal function in the elderly, the clinician must be aware that the formula relatively underestimates the true renal clearance.

© 1991 S. Karger AG, Basel


  

Author Contacts

Dr. R. Sainsbury, Assessment & Rehabilitation Unit, Princess Margaret Hospital, Private Bag, Christchurch (New Zealand)

  

Article Information

Accepted: March 15, 1991
Published online: December 11, 2008
Number of Print Pages : 5

  

Publication Details

Nephron

Vol. 59, No. 4, Year 1991 (Cover Date: 1991)

Journal Editor: Fine L.G. (Los Angeles, Calif.)
ISSN: 0028-2766 (Print), eISSN: 1423-0186 (Online)

For additional information: http://www.karger.com/NEF


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: 3/15/1991
Published online: 12/11/2008
Issue release date: 1991

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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