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Table of Contents
Vol. 60, No. 4, 1992
Issue release date: 1992
Section title: Original Paper
Nephron 1992;60:390–396
(DOI:10.1159/000186797)

Effect of Erythropoietin Treatment on Physical Exercise Capacity and on Renal Function in Predialytic Uremic Patients

Clyne N.a · Jogestrand T.b
aDivision of Nephrology, Department of Medicine, and bDepartments of Clinical Physiology, Karolinska and Huddinge Hospital, Stockholm, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: June 24, 1991
Published online: December 11, 2008
Issue release date: 1992

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

Anemia is already present in patients with moderate renal failure and is a major cause of the decline in exercise capacity seen in these patients. We examined the effects of erythropoietin (EPO) treatment in 12 predialytic uremic patients (EPO group: mean age 46 ± 12 years; 6 men, 6 women) with a mean glomerular filtration rate (GFR) of 10 ± 4 ml/min × 1.73 m2. These patients were compared to a control group of 8 patients (5 men, 3 women). The observation period was 3 months. The EPO group received 300 U/kg body weight i.v. once a week. The EPO group increased their total hemoglobin (THb) from 323 ± 89 to 466 ± 128 g (p < 0.001) and their hemoglobin concentration from 86 ± 8 to 117 + 11 g/l (p < 0.001). Their exercise capacity, measured by a standardized exercise test on a bicycle ergometer, increased from 128 ± 45 to 147 ± 57 W (p < 0.01). The control group did not change their THb (349 ± 124 and 357 ± 131 g), hemoglobin (93 ± 8 and 94 ± 10 g/l) or exercise capacity (98 ± 49 and 101 ± 50 W) during the observation period. There was a significant correlation between the increase in THb and the increase in exercise capacity in the EPO group (r = 0.81, p < 0.005). The GFR was unchanged in both groups (EPO group: 10 ± 4 and 10 + 6 ml/min × 1.73 m2; control group: 8 ± 3 and 8 ± 3 ml/min × 1.73 m2). The median renal plasma flow did not change significantly in either group (EPO group: 42 and 27 ml/ min × 1.73 m2; control group: 34 and 28 ml/min × 1.73 m2). The median filtration fraction, however, increased significantly in the EPO group (0.21 to 0.30; p < 0.05), while the filtration fraction in the control group was unchanged (0.22 and 0.25; NS). We conclude that erythropoietin treatment increases the THb in predialytic uremic patients, resulting in an improved exercise capacity without affecting GFR.

© 1992 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: June 24, 1991
Published online: December 11, 2008
Issue release date: 1992

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.