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Table of Contents
Vol. 62, No. 3, 1992
Issue release date: 1992
Section title: Original Paper
Nephron 1992;62:267–271
(DOI:10.1159/000187057)

Hemodialysis Intravascular Hemolysis and Kinked Blood Lines

Gault M.H. · Duffett S. · Purchase L. · Murphy J.
General Hospital and Memorial University, St. John’s, Nfld, Canada

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: 5/22/1992
Published online: 12/12/2008
Issue release date: 1992

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

Between May 29 and September 13,1991,4 patients developed acute intravascular hemolysis during hemodialysis with Monitral-S delivery systems and Hospal BSM A77 blood lines. All had malaise, nausea and headache; 3 had severe abdominal pain and 2 became very ill. Plasma hemoglobins were 3-21 g/l and LDH 542-3,300 IU in the 4 patients. Hepatoglobin became unmeasurable in 3 and was 0.09 g/l in the 4th patient. Soon afterwards, we found the arterial blood line tightly kinked at the dialyzer inlet port in the 4th patient and released it; he developed abdominal pain, hemolysis was present. We then found these lines had an extra long pump segment, and the rest was short and fitted poorly. When put in the first tubing organizer, severe kinking could occur just after the pump segment, causing back pressure but no alarm. We produced early visible hemolysis in a 1-liter circulating closed loop blood system with the blood line kinked either at the dialyzer inlet or just below the first arterial line tubing organizer with 40 g/l free plasma hemoglobin by 30 min. We excluded reported causes of intravascular hemolysis during hemodialysis. No hemolysis occurred before or during the 9 months after we discarded BSM A77 lines. The evidence indicates that kinked blood lines caused the hemolysis.

© 1992 S. Karger AG, Basel


  

Author Contacts

M.H. Gault, MD, Memorial University of Newfoundland, Health Sciences Centre, St. John’s Nfld. A1B 3V6 (Canada)

  

Article Information

Accepted: May 22, 1992
Published online: December 12, 2008
Number of Print Pages : 5

  

Publication Details

Nephron

Vol. 62, No. 3, Year 1992 (Cover Date: 1992)

Journal Editor: Fine L.G. (Los Angeles, Calif.)
ISSN: 0028-2766 (Print), eISSN: 1423-0186 (Online)

For additional information: http://www.karger.com/NEF


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: 5/22/1992
Published online: 12/12/2008
Issue release date: 1992

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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