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Original Paper

Association of DQB1*0302 Alloantigens in Japanese Pediatric Patients with Steroid-Sensitive Nephrotic Syndrome

Kuramitsu Abe K.a · Michinaga I.a · Hiratsuka T.a · Ogahara S.a · Naito S.b · Arakawa K.a · Tsuru N.c · Tokieda K.c

Author affiliations

aSecond Department of Internal Medicine, Fukuoka University School of Medicine, bKidney Center, Fukuoka University Hospital, and cPediatrics Department, Chikushi Hospital of Fukuoka University, Fukuoka, Japan

Related Articles for ""

Nephron 1995;70:28–34

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: March 31, 1994
Published online: December 18, 2008
Issue release date: 1995

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

We identified human leukocyte alloantigens (HLA) class II alleles in 24 Japanese children with steroid-sensitive nephrotic syndrome (SSNS) by deoxyribo-nucleic acid (DNA) typing. The DQA1 and DQB1 alleles were identified using sequence-specific oligonucleotide probes for DQA and DQB. The frequency of DQB1*0302 was significantly higher in the patients than in the controls (54.0 vs. 16.0%, respectively; relative risk, RR = 6.2; pc < 0.00009. We also found that the frequency of DQA1*0103 in the patients was significantly lower than in the controls (RR = 0.194, pc < 0.04). Several studies have identified an association between certain HLA by serotyping. In the present study, we investigated the HLAs of Japanese patients with SSNS by DNA typing and observed a significant increase in the frequency of DQB1*0302 in patients with the disease. HLA-DQ3, which was proven to be associated with SSNS, consists of HLA DQ7, 8 and 9. DQB 1*0302 is a component of HLA-DQ8. So we proposed the increase of DQ3 was due to an increase in DQ8.

© 1995 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: March 31, 1994
Published online: December 18, 2008
Issue release date: 1995

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


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