Creatinine Clearance: An Inadequate Marker of Renal Filtration in Patients with Early Posthepatitic Cirrhosis (Child A) without Fluid Retention and Muscle WastingDeSanto N.G. · Anastasio P. · Loguercio C. · Spitali L. · Del Vecchio Blanco C. · Corvinelli M. · Cirillo M.
Chair of Nephrology, Department of Pediatrics, and Chair of Gastroenterology, Seconda Università degli Studi, Naples, Italy
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Glomerular filtration rate (GFR) was measured in 19 patients with Child A liver cirrhosis by comparing the endogenous creatinine clearance with inulin clearance. Inulin clearance averaged 90 ± 4.4 ml/min × 1.73 m2, while creatinine clearance averaged 122 ± 7 ml/min × 1.73 m2 (p < 0.001). The overestimation of GFR by creatinine was present in 18 of 19 patients and was inversely correlated with inulin clearance (r = – 0.452, p < 0.04). The data point to the unsuitability of creatinine as a marker of filtration in early posthepatitic cirrhosis (Child A).
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