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Original Paper

Creatinine Clearance: An Inadequate Marker of Renal Filtration in Patients with Early Posthepatitic Cirrhosis (Child A) without Fluid Retention and Muscle Wasting

DeSanto N.G. · Anastasio P. · Loguercio C. · Spitali L. · Del Vecchio Blanco C. · Corvinelli M. · Cirillo M.

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Chair of Nephrology, Department of Pediatrics, and Chair of Gastroenterology, Seconda Università degli Studi, Naples, Italy

Related Articles for ""

Nephron 1995;70:421–424

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: August 09, 1994
Published online: December 18, 2008
Issue release date: 1995

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

Glomerular filtration rate (GFR) was measured in 19 patients with Child A liver cirrhosis by comparing the endogenous creatinine clearance with inulin clearance. Inulin clearance averaged 90 ± 4.4 ml/min × 1.73 m2, while creatinine clearance averaged 122 ± 7 ml/min × 1.73 m2 (p < 0.001). The overestimation of GFR by creatinine was present in 18 of 19 patients and was inversely correlated with inulin clearance (r = – 0.452, p < 0.04). The data point to the unsuitability of creatinine as a marker of filtration in early posthepatitic cirrhosis (Child A).

© 1995 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: August 09, 1994
Published online: December 18, 2008
Issue release date: 1995

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


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