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Table of Contents
Vol. 72, No. 3, 1996
Issue release date: 1996
Section title: Original Paper
Nephron 1996;72:391–394
(DOI:10.1159/000188901)

Calcium β-Hydroxy-β-Methylbutyrate

1. Potential Role as a Phosphate Binder in Uremia: In vitro Study

Sousa M.F.a · Abumrad N.N.b · Martins C.a · Nissen S.c · Riella M.C.a
aDepartment of Medicine, Nephrology Division, Evangelic School of Medicine, Curitiba, Brazil; bDepartment of Surgery, State University of New York, Stony Brook, N.Y., and cDepartment of Animal Sciences, Iowa State University, Ames, Iowa, USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: February 17, 1995
Published online: December 18, 2008
Issue release date: 1996

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

The binding capacity of calcium β-hydroxy-β-methylbutyrate (calcium HMB), compared to other binders, was investigated in an in vitro study. Fifty milli-equivalents of either calcium HMB, calcium acetate, calcium carbonate, aluminum hydroxide gel or non-gel aluminum hydroxide was added to a phosphate solution, titrated (HC1 or NaOH), shaken and centrifuged to four different pH levels at 37 °C (simulating the gastrointestinal milieu). The difference in phosphate concentration between that of the initial and that of the supernatant represented from the bound phosphate in the precipitate. After 4 h at a pH of 6 (representing the intestinal condition after a meal), the binding percentage was: calcium acetate = 95.6%, calcium HMB = 92.6%, calcium carbonate = 46.4%, aluminum hydroxide gel = 33.4% and non-gel aluminum hydroxide = 17.8%. There was no significant difference (p > 0.05) between calcium HMB and calcium acetate. These results suggest that calcium HMB is an efficient phosphate binder in vitro, which may predict its effective role in vivo.

© 1996 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: February 17, 1995
Published online: December 18, 2008
Issue release date: 1996

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


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