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Table of Contents
Vol. 73, No. 2, 1996
Issue release date: 1996
Section title: Original Paper
Nephron 1996;73:158–164
(DOI:10.1159/000189033)

Superinfection with Hepatitis C Virus in Hemodialysis Patients with Hepatitis B Surface Antigenemia: Its Prevalence and Clinical Significance in Taiwan

Division of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: 5/5/1995
Published online: 12/19/2008

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

A survey of hepatitis B surface antigen (HBsAg) and antibodies against hepatitis C virus (anti-HCV) in 173 patients undergoing hemodialysis in Taiwan revealed that 15 (9%) patients were positive for both HBsAg and anti-HCV, 106 (61%) were positive for anti-HCV alone, and 14 (8%) were positive for HBsAg alone. Most HBsAg positivity was acquired before the onset of hemodialysis. Anti-HCV positivity, however, was mainly acquired via the hemodialysis procedure. Patients with dual markers were younger (43.7 ± 3.3 years old, p = 0.0274), had the longest period on hemodialysis (6.6 ± 1.3 years, p < 0.001), and more severe liver dysfunction. When compared with those who were negative for both markers, patients with both HBsAg and anti-HCV had an increased incidence of chronicity (5/15 vs. 2/38; p < 0.05), ultrasonographic cirrhosis (5/15 vs. 1/38; p < 0.05), and clinical decompensation (2/15 vs. 0/38; p < 0.05). Their risk for developing ultrasonographic cirrhosis and clinical decompensation was also greater than that of patients with anti-HCV alone (5/15 vs. 8/106 and 2/15 vs. 2/106; p < 0.05 for both). The presence of HBsAg alone, however, did not increase the incidence of liver dysfunction. The presence of anti-HCV alone was only associated with a greater elevation of serum alanine aminotransferase (44.2 ± 5.5 vs. 19.1 ± 2.5 U/l; p < 0.05) and an increased incidence of chronicity (30/106 vs. 2/38; p < 0.05). Our results indicate that a high prevalence of HCV superinfection impose a significant risk on a large population of HBsAg-positive hemodialysis patients in Taiwan. As the coexistence of anti-HCV and HBsAg is associated with more severe liver dysfunction, it is urgent to devise effective methods to prevent HCV circulation in a hemodialysis environment – especially in a hepatitis B virus endemic area such as Taiwan.


  

Author Contacts

Kuo-Su Chen, MD, Division of Nephrology, Chang Gung Memorial Hospital, 222 Mai Chin Road, Keelung, Taiwan (ROC)

  

Article Information

Accepted: May 5, 1995
Published online: December 19, 2008
Number of Print Pages : 7

  

Publication Details

Nephron

Vol. 73, No. 2, Year 1996 (Cover Date: 1996)

Journal Editor: Fine L.G. (Los Angeles, Calif.)
ISSN: 0028-2766 (Print), eISSN: 1423-0186 (Online)

For additional information: http://www.karger.com/NEF


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: 5/5/1995
Published online: 12/19/2008

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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