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Vol. 74, No. 2, 1996
Issue release date: 1996
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Nephron 1996;74:261-265
Original Paper

α-Ketoglutarate Application in Hemodialysis Patients Improves Amino Acid Metabolism

Riedel E.a · Nündel M.a · Hampl H.b
aFreie Universität Berlin, Institut für Biochemie, und bKuratorium für Dialyse und Nierentransplantation, Berlin, Deutschland Nephron 1996;74:261-265 (DOI:10.1159/000189319)


In hemodialysis patients, free amino acids and α-ketoacids in plasma were determined by fluorescence HPLC to assess the effect of α-ketoglutarate administration in combination with the phosphate binder calcium carbonate on the amino acid metabolism. During 1 year of therapy in parallel to inorganic phosphate, urea in plasma decreased significantly, histidine, arginine and proline as well as branched chain α-ketoacids, in particular α-ketoisocaproate, a regulator of protein metabolism, increased. Thus, administration of α-ketoglutarate with calcium carbonate effectively improves amino acid metabolism in hemodialysis patients as it decreases hyperphosphatemia.

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Prof. Dr. Eberhard Riedel, Institut für Biochemie, Freie Universität Berlin, Limonenstrasse 7, D-12203 Berlin-Lichterfelde (Germany)

 goto top of outline Article Information

Accepted: October 31, 1995
Published online: December 24, 2008
Number of Print Pages : 5

 goto top of outline Publication Details


Vol. 74, No. 2, Year 1996 (Cover Date: 1996)

Journal Editor: Fine L.G. (Los Angeles, Calif.)
ISSN: 0028-2766 (Print), eISSN: 1423-0186 (Online)

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