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Vol. 74, No. 2, 1996
Issue release date: 1996
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Nephron 1996;74:261-265
(DOI:10.1159/000189319)
Original Paper

α-Ketoglutarate Application in Hemodialysis Patients Improves Amino Acid Metabolism

Riedel E.a · Nündel M.a · Hampl H.b
aFreie Universität Berlin, Institut für Biochemie, und bKuratorium für Dialyse und Nierentransplantation, Berlin, Deutschland Nephron 1996;74:261-265 (DOI:10.1159/000189319)

Abstract

In hemodialysis patients, free amino acids and α-ketoacids in plasma were determined by fluorescence HPLC to assess the effect of α-ketoglutarate administration in combination with the phosphate binder calcium carbonate on the amino acid metabolism. During 1 year of therapy in parallel to inorganic phosphate, urea in plasma decreased significantly, histidine, arginine and proline as well as branched chain α-ketoacids, in particular α-ketoisocaproate, a regulator of protein metabolism, increased. Thus, administration of α-ketoglutarate with calcium carbonate effectively improves amino acid metabolism in hemodialysis patients as it decreases hyperphosphatemia.

 goto top of outline Author Contacts

Prof. Dr. Eberhard Riedel, Institut für Biochemie, Freie Universität Berlin, Limonenstrasse 7, D-12203 Berlin-Lichterfelde (Germany)


 goto top of outline Article Information

Accepted: October 31, 1995
Published online: December 24, 2008
Number of Print Pages : 5


 goto top of outline Publication Details

Nephron

Vol. 74, No. 2, Year 1996 (Cover Date: 1996)

Journal Editor: Fine L.G. (Los Angeles, Calif.)
ISSN: 0028-2766 (Print), eISSN: 1423-0186 (Online)

For additional information: http://www.karger.com/NEF


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