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Table of Contents
Vol. 58, No. 3-4, 2008
Issue release date: March 2009
Section title: Original Paper
Free Access
Neuropsychobiology 2008;58:178–186

Pharmacological Modulation of Dopaminergic Brain Activity and Its Reflection in Spectral Frequencies of the Rat Electropharmacogram

Dimpfel W.
Justus Liebig University Giessen, Giessen, Germany
email Corresponding Author

Wilfried Dimpfel

Justus Liebig University Giessen

c/o NeuroCode AG, Sportparkstrasse 9

DE–35578 Wetzlar (Germany)

Tel. +49 6441 200 2033, Fax +49 6441 200 2039, E-Mail w.dimpfel@neurocode-ag.com

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Background: Particular frequencies of electropharmacograms have been attributed to cholinergic, noradrenergic or dopaminergic mediated neurotransmission. This investigation deals with changes induced by L-DOPA or dopamine D2 receptor agonists. Method: Adult rats (day-night converted) were instrumented with four bipolar concentric semi-micro-electrodes into the frontal cortex, hippocampus, striatum and reticular formation. Field potentials were recorded during a pre-drug reference period followed by 4 h of recording thereafter. Data were transmitted wirelessly for spectral frequency analysis. Results: At low doses of L-DOPA (1–5 mg kg–1) and of the D2 agonists talipexole and quinpirole (0.1 mg kg–1), a delayed increase of delta and theta power was observed. Higher doses led to immediate stable decreases of alpha1, alpha2 and beta1 power as reported for dopamine D1 receptor agonists. Administration of the D2 blocker sulpiride (10–20 mg kg–1) resulted in increases of alpha2 power. Conclusion: A common denominator for changes of dopaminergic transmission could be seen in immediate changes of spectral alpha2 power. Delayed increases of delta and theta activity after low dosages of the medication are considered to originate from heterosynaptic, presynaptic D2 receptors sitting on cholinergic neurons. This pattern could explain daytime tiredness or sudden sleep attacks in Parkinson patients.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 26, 2008
Accepted: October 25, 2008
Published online: January 14, 2009
Issue release date: March 2009

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

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