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Table of Contents
Vol. 79, No. 1, 2009
Issue release date: March 2009
Section title: Original Paper
Digestion 2009;79:1–4
(DOI:10.1159/000191204)

Past Rifampicin Dosing Determines Rifabutin Resistance of Helicobacter pylori

Suzuki S.a · Suzuki H.a · Nishizawa T.a · Kaneko F.b · Ootani S.c · Muraoka H.d · Saito Y.a · Kobayashi I.e · Hibi T.a
aDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, bDepartment of Gastroenterology, Kitasato Institute Medical Center Hospital, Kitasato University, cDepartment of Internal Medicine, National Minami-Yokohama Hospital, dDepartment of Antimicrobial Therapy, Mitsubishi Chemical Medience, and eDepartment of Infection Control and Prevention, Faculty of Medicine, Toho University, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 11, 2008
Accepted: November 25, 2008
Published online: January 14, 2009
Issue release date: March 2009

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Background: Recently, the number of Helicobacter pylori isolates showing antibiotic resistance has been increasing. Rifabutin (RFB) is one of the possible candidates for H. pylori eradication. In the present study, the RFB minimum inhibitory concentrations (MICs) and the resistance-determining genes to RFB (rpoB) were examined to clarify the relationship between drug MICs, rpoB mutations, and past history of rifampicin (RFP) treatment. Methods: The MICs of RFB and rpoB mutations were examined for 48 strains with failure of H. pylori eradication in the University Hospital and 46 isolated from patients at a specialized hospital for chronic respiratory diseases without past H. pylori eradication. Past RFP treatment was also examined. Results: Eight of 94 strains showed high RFB MICs and 6 of the 8 strains showed rpoB point mutations. Although no strains showed high RFB MICs among 48 strains from the patients in the University Hospital, all 7 strains isolated from patients with past RFP treatment showed high RFB MICs (≥0.12 mg/l). Conclusion: Although RFB might be a potential candidate component of a new H. pylori eradication regimen following the first- or second-line failure, it should be used after examining a past history of RFP treatment.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 11, 2008
Accepted: November 25, 2008
Published online: January 14, 2009
Issue release date: March 2009

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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