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Vol. 17, No. 4, 2000
Issue release date: November 2000
Section title: Original Paper
Exp Clin Immunogenet 2000;17:179–184
(DOI:10.1159/000019137)

Lack of Association between CD28/CTLA-4 Gene Polymorphisms and Atopic Asthma in the Japanese Population

Nakao F.a · Ihara K.a · Ahmed S.a · Sasaki Y.a · Kusuhara K.a · Takabayashi A.b · Nishima S.b · Hara T.a
aDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, and bNational Minami-Fukuoka Chest Hospital, Fukuoka, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 11/29/2000
Issue release date: November 2000

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2

ISSN: 0254-9670 (Print)
eISSN: 1421-9948 (Online)

For additional information: http://www.karger.com/ECI

Abstract

Atopic asthma occurs in genetically susceptible individuals in the presence of environmental factors. Recently, the costimulation signal from CD80-CD86 to CD28/CTLA-4 has been suggested to play an important role in the development of atopic asthma. In the present study, we analyzed three polymorphic regions within the CTLA-4 gene, an A/G substitution in exon 1 position 49, a C/T base exchange in the promoter position –318 and an (AT)n repeat polymorphism in the 3′-untranslated region of exon 4, and a CD28 gene polymorphism with a T/C substitution in intron 3 position +17 in 120 patients with atopic asthma and 200 normal controls. The polymorphism frequencies of CTLA-4/CD28 genes in patients did not differ from those in normal controls. Thus, the present study was unable to reveal any association between CTLA-4/CD28 gene polymorphisms and atopic asthma in the Japanese population.

© 2000 S. Karger AG, Basel


  

Author Contacts

F. Nakao, Department of Pediatrics
Graduate School of Medical Sciences, Kyushu University
3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 (Japan)
Tel. +81 92 642 5421, Fax +81 92 642 5435
E-Mail nakaof@pediatr.med.kyushu-u.ac.jp

  

Article Information

Received: Received: June 23, 1999
Revised version: Dec. 6, 1999
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 2, Number of References : 20

  

Publication Details

Experimental and Clinical Immunogenetics

Vol. 17, No. 4, Year 2000 (Cover Date: Released November 2000)

Journal Editor: K. Bauer, Heidelberg
ISSN: 0254–9670 (print), 1421–9948 (Online)

For additional information: http://www.karger.com/journals/eci


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 11/29/2000
Issue release date: November 2000

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2

ISSN: 0254-9670 (Print)
eISSN: 1421-9948 (Online)

For additional information: http://www.karger.com/ECI


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