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Original Paper

Lack of Association between CD28/CTLA-4 Gene Polymorphisms and Atopic Asthma in the Japanese Population

Nakao F.a · Ihara K.a · Ahmed S.a · Sasaki Y.a · Kusuhara K.a · Takabayashi A.b · Nishima S.b · Hara T.a

Author affiliations

aDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, and bNational Minami-Fukuoka Chest Hospital, Fukuoka, Japan

Related Articles for ""

Exp Clin Immunogenet 2000;17:179–184

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: November 29, 2000
Issue release date: November 2000

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2

ISSN: 0254-9670 (Print)
eISSN: 1421-9948 (Online)

For additional information: http://www.karger.com/ECI

Abstract

Atopic asthma occurs in genetically susceptible individuals in the presence of environmental factors. Recently, the costimulation signal from CD80-CD86 to CD28/CTLA-4 has been suggested to play an important role in the development of atopic asthma. In the present study, we analyzed three polymorphic regions within the CTLA-4 gene, an A/G substitution in exon 1 position 49, a C/T base exchange in the promoter position –318 and an (AT)n repeat polymorphism in the 3′-untranslated region of exon 4, and a CD28 gene polymorphism with a T/C substitution in intron 3 position +17 in 120 patients with atopic asthma and 200 normal controls. The polymorphism frequencies of CTLA-4/CD28 genes in patients did not differ from those in normal controls. Thus, the present study was unable to reveal any association between CTLA-4/CD28 gene polymorphisms and atopic asthma in the Japanese population.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: November 29, 2000
Issue release date: November 2000

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 2

ISSN: 0254-9670 (Print)
eISSN: 1421-9948 (Online)

For additional information: http://www.karger.com/ECI


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