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Table of Contents
Vol. 113, No. 3, 2009
Issue release date: May 2009
Section title: Original Research
Cardiology 2009;113:184–192
(DOI:10.1159/000193146)

Evaluation of Right Ventricular Systolic and Diastolic Function in Patients with Newly Diagnosed Obstructive Sleep Apnea Syndrome without Hypertension

Tugcu A.a · Guzel D.a · Yildirimturk O.a · Aytekin S.a, b
aDivision of Cardiology, Florence Nightingale Hospital, and bDivision of Cardiology, Medical Faculty, T.C. Istanbul Bilim University, Istanbul, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: August 12, 2008
Accepted: November 06, 2008
Published online: January 19, 2009
Issue release date: May 2009

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 5

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Objectives: We investigated right ventricular (RV) structural and functional cardiac alterations in obstructive sleep apnea (OSA) independent of systemic hypertension and their correlation to the severity of OSA. Methods: Forty-one moderate-to-severe OSA but otherwise healthy patients and 30 body mass index-matched control subjects were included. All subjects underwent 24-hour ambulatory blood pressure monitoring, standard and tissue Doppler imaging of the RV. Results: The OSA group had increased RV wall thickness, impaired right ventricular outflow tract fractional shortening (RVOT fs), tricuspid annular plane systolic excursion (TAPSE), RV myocardial performance index (MPI) and RV myocardial acceleration during isovolumic contraction (IVA) (p < 0.001). Apnea hypopnea index (AHI) and mean pulmonary artery (PA) pressure were correlated with all these indices (p < 0.01 for all). RV free wall thickness (p < 0.001) and IVA (p = 0.006) remained significant predictors of AHI after adjusting for age, body mass index, mean PA pressure, RVOT fs, TAPSE and MPI in a multiple stepwise linear regression model. Conclusions: OSA is associated with impaired RV function despite normal systemic blood pressures. The level of RV dysfunction has a direct relationship with the severity of OSA. RV free wall thickness and IVA are independent predictors of AHI in uncomplicated OSA patients.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: August 12, 2008
Accepted: November 06, 2008
Published online: January 19, 2009
Issue release date: May 2009

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 5

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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