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Table of Contents
Vol. 51, No. 3, 1987
Issue release date: 1987
Section title: Original Paper
Respiration 1987;51:232–240
(DOI:10.1159/000195206)

Maternal Nicotine Exposure and Carbohydrate Metabolism of Fetal and Neonatal Lung Tissue: Response to Nicotine Withdrawal

Maritz G.S.
Department of Physiological Sciences, University of the Western Cape, Bellville, South Africa

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 11, 1985
Accepted: October 14, 1986
Published online: January 16, 2009
Issue release date: 1987

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

The metabolic response of fetal and neonatal lung tissue to maternal nicotine exposure (0.25 and 1.0 mg/kg body weight/day) was investigated. White virgin female rats (Wistar) of 200–250 g were used. The rats were mated overnight and were afterwards randomly assigned to control and experimental groups. The experimental group was subdivided into two groups. One group received nicotine during pregnancy and lactation. The second group received nicotine only during lactation. The suckling rats were killed 24 h after the last dose of nicotine was administered to the mother. The lung tissue was surgically removed and the in vitro utilization of exogenous glucose and endogenous glycogen determined. Lactate production was also determined to assess glycolytic activity. Maternal nicotine administration during pregnancy and lactation stimulated total glucose turnover by 21.6 and 86.4% respectively but suppressed glycogenolysis (32.7%) and glycolysis by 24.6% (p < 0.01). Nicotine administration during lactation only enhanced total glucose turnover by 19.1% (p < 0.01) and glycogenolysis by 30% (p < 0.01) but inhibited glycolysis by 25.8%. After 4 weeks of nicotine withdrawal when the rats were 7 weeks old, glycogenolysis and glycolysis of those animals exposed to nicotine via the placenta and mother’s milk were still inhibited to the same extent as during exposure. Glycogenolysis and the glycolytic flux of lung tissue of rats exposed to nicotine via mother’s milk only returned to normal. Since rat lung tissue has reached maturation at this stage, it is conceivable to assume that exposure to nicotine during pregnancy will have a permanent adverse effect on carbohydrate metabolism in lung tissue and thus on the aspects of lung development and differentiation dependent on these pathways.

© 1987 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 11, 1985
Accepted: October 14, 1986
Published online: January 16, 2009
Issue release date: 1987

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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