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Table of Contents
Vol. 33, No. 2, 1998
Issue release date: February 1998
Section title: Clinical Paper
Eur Urol 1998;33:144–151
(DOI:10.1159/000019546)

Maximal Androgen Blockade: Final Analysis of EORTC Phase III Trial 30853

Denis L.J. · Keuppens F. · Smith P.H. · Whelan P. · Carneiro de Moura J.L. · Newling D. · Bono A. · Sylvester R.
Departments of Urology, A.Z. Middelheim, Antwerp, and Vrije Universiteit, Brussels, Belgium;St. James’ University Hospital, Leeds, UK;Hospital Santa Maria, Lisbon, Portugal;Free University Hospital, Amsterdam, The Netherlands;Ospedale di Circolo e Fondazione E.S. Macchi, Varese, Italy;EORTC Data Center, Brussels, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Clinical Paper

Published online: 2/13/1998
Issue release date: February 1998

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 5

ISSN: 0302-2838 (Print)
eISSN: 1421-993X (Online)

For additional information: http://www.karger.com/EUR

Abstract

Objectives: This prospective, randomized phase III study was initiated to compare the efficacy and side effects of bilateral orchiectomy versus a combination of a luteinizing hormone-releasing hormone agonist depot formulation, goserelin acetate (3.6 mg s.c. once every 4 weeks) and flutamide (250 mg 3× daily) in patients with metastatic prostate cancer. Methods: Relative treatment efficacy was assessed by comparing the two treatment groups with respect to response, time to first progression, progression-free survival, duration of survival and time to death due to malignant disease. Results: There was a difference in response only with respect to a more frequent decrease to normal of the serum prostate acid phosphatase in patients assigned to maximal androgen blockade treatment. Additionally, maximal androgen blockade treatment showed significantly better results for duration of survival (p = 0.04), time to death due to malignant disease (p = 0.008), time to first progression (p = 0.009) and progression-free survival (p = 0.02). The most frequent side effects for both treatments included hot flushes and gynaecomastia. Conclusions: Increased time to progression and duration of survival is achieved by the combination of flutamide and goserelin when compared to bilateral orchiectomy.


  

Author Contacts

Prof. Dr. L.J. Denis
Oncologisch Centrum Antwerpen
B–2020 Antwerpen (Belgium)
Tel. +32 3 280 36 02, Fax +32 3 218 46 96

  

Article Information

Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 5, Number of References : 14

  

Publication Details

European Urology ()

Official Organ of the European Association of Urology

Vol. 33, No. 2, Year 1998 (Cover Date: February 1998)

Journal Editor: C.C. Schulman, Brussels
ISSN: 0302–2838 (print), 1421–993X (Online)

For additional information: http://www.karger.ch/journals/eur


Article / Publication Details

First-Page Preview
Abstract of Clinical Paper

Published online: 2/13/1998
Issue release date: February 1998

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 5

ISSN: 0302-2838 (Print)
eISSN: 1421-993X (Online)

For additional information: http://www.karger.com/EUR


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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