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Table of Contents
Vol. 62, No. 2, 1995
Issue release date: 1995
Section title: Original Paper
Respiration 1995;62:64–69
(DOI:10.1159/000196393)

Aberrant Appearance of Lung Surfactant Protein A in Sera of Patients with Idiopathic Pulmonary Fibrosis and Its Clinical Significance

Honda Y.a · Kuroki Y.b · Shijubo N.a · Fujishima T.a · Takahashi H.a · Hosoda K.c · Akino T.b · Abe S.a
Departments of aThird Internal Medicine and bBiochemistry, Sapporo Medical University School of Medicine, Sapporo, and cTeijin Institute of Bio Medicine, Hino, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 24, 1994
Accepted: September 22, 1994
Published online: January 21, 2009
Issue release date: 1995

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Pulmonary surfactant protein A (SP-A) is known to be a major phospholipid-associated glycoprotein in pulmonary surfactant, which is specific to the lung. In this study, the SP-A concentrations in sera of patients with various lung diseases were determined using an enzyme-linked immunosorbent assay. Patients with idiopathic pulmonary fibrosis (IPF) and pulmonary alveolar proteinosis (PAP) exhibited prominently high concentrations of serum SP-A compared to those of other lung diseases and healthy volunteers, although there were significant increases in serum SP-A concentrations in patients with pulmonary tuberculosis, chronic pulmonary emphysema, diffuse panbronchiolitis and bacterial pneumonia compared to those of healthy volunteers. Successive measurement in 2 patients with IPF showed that serum SP-A levels reflect the disease activity of IPF. In patients with IPF, serum SP-A concentrations were significantly correlated with those of serum lactate dehydrogenase, whereas there were no significant correlations of serum SP-A concentrations with erythrocyte sedimentation rate, arterial oxygen saturation, vital capacity and carbon monoxide diffusing capacity. Determination of serum SP-A will contribute to diagnosing IPF and PAP, and may reflect the disease activity of IPF.

© 1995 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 24, 1994
Accepted: September 22, 1994
Published online: January 21, 2009
Issue release date: 1995

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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