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Table of Contents
Vol. 63, No. 5, 1996
Issue release date: 1996
Section title: Original Paper
Respiration 1996;63:292–297
(DOI:10.1159/000196563)

IgA Immune Response against the Mycobacterial Antigen A60 in Patients with Active Pulmonary Tuberculosis

Alifano M.a · Sofia M.a · Mormile M.a · Micco A.a · Mormile A.F.a · Del Pezzo M.b · Carratù L.a
aInstitute of Respiratory Disease and bClinical Microbiology, Department of Cellular and Molecular Biology and Pathology, University of Naples ‘Federico II’, Naples, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 02, 1995
Accepted: November 30, 1995
Published online: January 21, 2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Searching for IgG and IgM against the mycobacterial antigen A60 has been recognized as a potential diagnostic tool for pulmonary tuberculosis. The role of detection of anti-A60 IgA in improving diagnostic accuracy of serology is not well known. In this study we measured with ELISA serum levels of both anti-A60 IgG and IgA in 216 subjects. 88 healthy volunteers (44 PPD- and 44 PPD+), 44 patients suffering from nontuberculous lung disease and 15 subjects with healed pulmonary tuberculosis constituted the control population; 69 patients with active pulmonary tuberculosis (35 cavitary forms, 26 productive forms and 8 miliary forms) were examined. The sensitivity of IgG test was 73.9% in pulmonary tuberculosis (77.1% in cavitary forms, 65.4% in productive forms, 87.5% in milary forms); the specificity of the test was 95.9%. For the IgA test we observed a sensitivity of 72.5% (74.3 in cavitary forms, 69.2% in productive forms, 75.0 in miliary forms) and a specificity of 93.9%. Combination of the two tests increased the sensitivity to 84.0% (+10.1 % compared to IgG test, +11.5% compared to IgA test); the specificity decreased to 92.5% (-3.4% vs. IgG test; -1.4 vs. IgA test). In conclusion, the combined use of evaluation of anti-A60 IgG and IgA increases the accuracy of serological diagnosis of pulmonary tuberculosis.

© 1996 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 02, 1995
Accepted: November 30, 1995
Published online: January 21, 2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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