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Table of Contents
Vol. 27, No. 3, 2009
Issue release date: March 2009
Section title: Original Paper
Cerebrovasc Dis 2009;27:254–258
(DOI:10.1159/000196824)

Utilization of Intravenous Tissue Plasminogen Activator for Ischemic Stroke: Are There Sex Differences?

Allen N.B. · Myers D. · Watanabe E. · Dostal J. · Sama D. · Goldstein L.B. · Lichtman J.H.
aSection of Chronic Disease Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn., bUHC University HealthSystem Consortium, Oak Brook, Ill., cDepartment of Medicine (Neurology), Duke Center for Cerebrovascular Disease, Center for Clinical Health Policy Research, Duke University and Durham VAMC, Durham, N.C., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/3/2008
Accepted: 10/17/2008
Published online: 1/29/2009

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: We evaluated whether there were sex-related differences in the administration of intravenous tissue plasminogen activator (IV-tPA) to patients with acute ischemic stroke admitted to US academic medical centers. Methods: Medical records were abstracted for consecutive ischemic stroke patients admitted to 32 academic medical centers from January through June, 2004, as part of the University HealthSystem Consortium Ischemic Stroke Benchmarking Project. Multivariate logistic models were used to test for sex-related differences in the receipt of IV-tPA with adjustment for demographic and clinical factors. Results: The study included 1,234 patients (49% women; mean age 66.6 years; 56% white). IV-tPA was given to 7% (6.5% of women versus 7.5% of men, p = 0.49). Women and men were equally likely to receive IV-tPA in risk-adjusted analyses (OR 1.02, 95% CI 0.64–1.64). Approximately 77% of women and men who did not receive IV-tPA did not meet the 3-hour treatment window or their time of onset was unknown. Conclusions: Women admitted to academic hospitals receive IV-tPA as often as men; however, a substantial percentage of both women and men are not arriving within the 3-hour time window required for diagnostic assessment and administration of intravenous thrombolytic therapy. Additional efforts are needed to improve the rapid identification, evaluation and treatment of stroke patients.


  

Author Contacts

Dr. Judith H. Lichtman
Yale University School of Medicine
PO Box 208034
New Haven, CT 06520-8034 (USA)
Tel. +1 203 785 3025, Fax +1 203 785 6980, E-Mail judith.lichtman@yale.edu

  

Article Information

Received: September 3, 2008
Accepted: October 17, 2008
Published online: January 29, 2009
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 4, Number of References : 22

  

Publication Details

Cerebrovascular Diseases

Vol. 27, No. 3, Year 2009 (Cover Date: March 2009)

Journal Editor: Hennerici M.G. (Mannheim)
ISSN: 1015-9770 (Print), eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/3/2008
Accepted: 10/17/2008
Published online: 1/29/2009

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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