The management of frontotemporal dementia (FTD), a disorder characterized by varied behavioralsymptoms, primarily involves the use of psychoactive medications. Although there are no approvedtreatments for the disorder, selective serontonin receptor inhibitors, such as sertraline, paroxetine, orfluoxetine, can decrease disinhibition-impulsivity, repetitive behaviors, and eating disorders in FTD.Low doses of trazodone or an atypical antipsychotic such as aripriprazole can also help manage significantlydisturbed or agitated behavior. The acetylcholinesterase inhibitors used for patients withAlzheimer’s disease have not had significant efficacy for patients with FTD, but memantine, anotherdementia medication, is under investigation for the treatment of this disorder. In addition to drugtherapy, the nonpharmacological management of patients with FTD focuses on education, behavioralinterventions, and care of the caregivers. Most recently, investigators have initiated steps towardrational drug therapy with the development of outcome measures for clinical drug trials in FTD andthe characterization of treatment targets such tau protein or the TAR DNA-binding protein 43. Thisapproach holds great promise for an eventual treatment for this devastating early-onset dementia.
Mario F. Mendez, MD, PhD
Neurobehavior Unit (116AF)
V.A. Greater Los Angeles Healthcare System
11301 Wilshire Blvd., Los Angeles, CA 90073 (USA)
Tel. +1 310 478 3711
Fax +1 310 268 4181
Number of Print Pages : 11
Book Serie: Frontiers of Neurology and Neuroscience, Vol. 24, Year 2009
Editor(s): Bogousslavsky, J. (Montreux)
ISSN: 1660-4431 (Print), eISSN: 1662-2804 (Online)
For additional information:
Book Title: Dementia in Clinical Practice
Editor(s): Giannakopoulos P, Hof PR (eds)
For additional information:
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