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Table of Contents
Vol. 49, No. 2, 2009
Issue release date: March 2009
Section title: Original Paper
Gynäkol Geburtshilfliche Rundsch 2009;49:94–99
(DOI:10.1159/000197908)

Placental Growth Factor: A Predictive Marker for Preeclampsia?

Schmidt M.a · Dogan C.a · Birdir C.a · Kuhn U.a · Gellhaus A.b · Kimmig R.a · Kasimir-Bauer S.a
aDepartment of Gynecology and Obstetrics and bInstitute for Anatomy, University of Duisburg-Essen, Essen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 05, 2008
Accepted: May 06, 2008
Published online: March 25, 2009
Issue release date: March 2009

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 1018-8843 (Print)
eISSN: 1423-0011 (Online)

For additional information: http://www.karger.com/GGR

Abstract

Background: An imbalance between angiogenic and antiangiogenic factors plays a fundamental role in the pathogenesis of preeclampsia. Serum levels of placental growth factor (PLGF), a factor promoting angiogenesis, in patients with preeclampsia are significantly lower than in nonpreeclamptic pregnancies. This study was designed to answer the question whether the measurement of PLGF at the beginning of the second trimester might be a predictive factor for the appearance of preeclampsia. Methods: Serum samples of 61 women were collected between 15 and 18 weeks of pregnancy. PLGF levels were measured using a human PLGF ELISA and correlated with the outcomes of pregnancy. Results: 7 women (11.47%) developed preeclampsia during pregnancy. Their PLGF levels between 15 and 18 weeks of pregnancy were significantly lower (p < 0.001) compared to the nonpreeclamptic pregnancies. Using a PLGF level of 41.84 pg/ml as a cutoff, this test has a sensitivity of 0.87 and a specificity of 0.83. Conclusion: Women who will develop preeclampsia in the course of pregnancy already have a significantly lower expression of PLGF between 15 and 18 weeks of pregnancy compared to those who will not. This test offers new possibilities in the prediction of preeclampsia.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 05, 2008
Accepted: May 06, 2008
Published online: March 25, 2009
Issue release date: March 2009

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 1018-8843 (Print)
eISSN: 1423-0011 (Online)

For additional information: http://www.karger.com/GGR


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