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Vol. 15, No. 5, 1977
Issue release date: 1977
Section title: Original Paper
Digestion 1977;15:411–424
(DOI:10.1159/000198029)

‘Luminal Nutrition’ versus ‘Functional Work-Load’ as Controllers of Mucosal Morphology and Epithelial Replacement in the Rat Small Intestine

Clarke R.M.
Department of Human Morphology, University Hospital and Medical School, Nottingham

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/9/1976
Accepted: 12/15/1976
Published online: 1/27/2009

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Isotonic solutions of substrate were infused into surgically prepared sacs of upper small intestine in conscious unrestrained rats which fed normally via the gut-in-continuity. Infusion of glucose, galactose or sodium chloride all caused a local increase in villus height, while α-methyl glucoside and mannose had no effect. Glucose, galactose and α-methyl glucoside all stimulated a similar increase in counts of vincristine metaphases in microdissected crypts, although the absolute level of cell production was lower throughout the gut in glucose-infused rats. Sodium chloride infusion also caused a small stimulation of cell production locally, but a considerable increase in the uninfused gut-in-continuity. Mannose infusion had a variable effect on cell production. These results do not support ‘luminal nutrition’ as a controller of epithelial replacement in the rat small intestine, and suggest that a mechanism based on the work-load of the epithelium may be more appropriate.


  

Author Contacts

Prof. R. Clarke, Faculty of Medicine, University of Newcastle, Newcastle, N.S.W. 2308 (Australia)

  

Article Information

Received: August 9, 1976
Accepted: December 15, 1976
Published online: January 27, 2009
Number of Print Pages : 14

  

Publication Details

Digestion (International Journal of Gastroenterology)

Vol. 15, No. 5, Year 1977 (Cover Date: 1977)

Journal Editor: Beglinger C. (Basel), Göke B. (Munich)
ISSN: 0012-2823 (Print), eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/9/1976
Accepted: 12/15/1976
Published online: 1/27/2009

Number of Print Pages: 14
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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