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Vol. 21, No. 5, 1981
Issue release date: 1981
Section title: Original Paper
Digestion 1981;21:232–243
(DOI:10.1159/000198568)

Origins of Neutral Sterols in Human Feces Studied by Stable Isotope Labeling (D and 13C). Existence of an External Secretion of Cholesterol

Férézou J. · Coste T. · Chevallier F.
Laboratoire de Physiologie de la Nutrition, Universiié de Paris Sud, Orsay, and Hôpital Avicenne, Université de Paris XHIe, Bobigny, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/11/1980
Published online: 1/28/2009
Issue release date: 1981

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

An experimental procedure using stable isotope-labeled cholesterol (13C and D) was carried out on 15 healthy subjects to distinguish the different origins of neutral fecal sterols in man: nonabsorption of dietary cholesterol, fecal excretion by transfer of plasmatic cholesterol and external secretion of cholesterol biosynthetized in digestive tract and directly eliminated. For a mean daily mass of 652 mg of fecal cholesterol, unabsorbed dietary cholesterol is 20% (133 mg), excreted cholesterol 67% (434 mg) and cholesterol from external secretion 13% (85 mg). A short treatment (4 days) with cholestyramine or different bile acids was then administered to each subject to study the possible variations in their fecal elimination of cholesterol. The more evident effect was the large stimulation of external secretion of cholesterol (234 mg/day) observed after chenodeoxycholic acid feeding (1 g/day). This treatment tends also to decrease dietary cholesterol absorption and to enhance excretion of cholesterol.

© 1981 S. Karger AG, Basel


  

Article Information

Received: January 11, 1980
Received in revised form: May 27, 1980
Published online: January 28, 2009
Number of Print Pages : 12

  

Publication Details

Digestion (International Journal of Gastroenterology)

Vol. 21, No. 5, Year 1981 (Cover Date: 1981)

Journal Editor: Beglinger C. (Basel), Göke B. (Munich)
ISSN: 0012-2823 (Print), eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/11/1980
Published online: 1/28/2009
Issue release date: 1981

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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