Origins of Neutral Sterols in Human Feces Studied by Stable Isotope Labeling (D and 13C). Existence of an External Secretion of CholesterolFérézou J. · Coste T. · Chevallier F.
Laboratoire de Physiologie de la Nutrition, Universiié de Paris Sud, Orsay, and Hôpital Avicenne, Université de Paris XHIe, Bobigny, France
An experimental procedure using stable isotope-labeled cholesterol (13C and D) was carried out on 15 healthy subjects to distinguish the different origins of neutral fecal sterols in man: nonabsorption of dietary cholesterol, fecal excretion by transfer of plasmatic cholesterol and external secretion of cholesterol biosynthetized in digestive tract and directly eliminated. For a mean daily mass of 652 mg of fecal cholesterol, unabsorbed dietary cholesterol is 20% (133 mg), excreted cholesterol 67% (434 mg) and cholesterol from external secretion 13% (85 mg). A short treatment (4 days) with cholestyramine or different bile acids was then administered to each subject to study the possible variations in their fecal elimination of cholesterol. The more evident effect was the large stimulation of external secretion of cholesterol (234 mg/day) observed after chenodeoxycholic acid feeding (1 g/day). This treatment tends also to decrease dietary cholesterol absorption and to enhance excretion of cholesterol.
© 1981 S. Karger AG, Basel
J. Férézou, Laboratoire de Physiologie de la Nutrition, Université de Paris Sud, Bâtiment 447, F-91405 Orsay Cédex (France)
Received: January 11, 1980
Received in revised form: May 27, 1980
Published online: January 28, 2009
Number of Print Pages : 12
Digestion (International Journal of Gastroenterology)
Vol. 21, No. 5, Year 1981 (Cover Date: 1981)
Journal Editor: Beglinger C. (Basel), Göke B. (Munich)
ISSN: 0012-2823 (Print), eISSN: 1421-9867 (Online)
For additional information: http://www.karger.com/DIG