Journal Mobile Options
Table of Contents
Vol. 35, No. 5-6, 1999
Issue release date: May–June 1999
Section title: Genetic and Environmental Factors in Prostate Cancer Genesis
Eur Urol 1999;35:355–361
(DOI:10.1159/000019909)

Androgen Metabolism and Prostate Cancer: Establishing a Model of Genetic Susceptibility

Ross R.K. · Coetzee G.A. · Pearce C.L. · Reichardt J.K.V. · Bretsky P. · Kolonel L.N. · Henderson B.E. · Lander E. · Altshuler D. · Daley G.
Departments of aPreventive Medicine, bUrology; cInstitute for Genetic Medicine, USC School of Medicine, Los Angeles, Calif.; dEpidemiology Program, University of Hawaii at Manoa Cancer Research Center, Honolulu, Hawaii; eWhitehead Institute/MIT, Center for Genome Research, fDepartment of Biology, MIT, and gDepartment of Medicine, Massachusetts General Hospital, Boston, Mass., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Genetic and Environmental Factors in Prostate Cancer Genesis

Published online: 4/16/2012

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 0302-2838 (Print)
eISSN: 1421-993X (Online)

For additional information: http://www.karger.com/EUR

Abstract

The prostate is an androgen-regulated organ, which has led to longstanding interest in the role of androgens in prostate carcinogenesis. Although evidence of a hormonal etiology for prostate cancer is strong, it is almost entirely circumstantial. Much of the problem in proving a causal relationship relates to the continued difficulties in reliably measuring human tissue-specific exposure to endogenous steroid hormones. The international and racial-ethnic variations in prostate cancer incidence, combined with the effects of migration on risk patterns, have suggested that genetic factors play a central role in determining prostate cancer risk. We are developing a polygenic model of prostate carcinogenesis, focused around a series of genes involved in androgen biosynthesis, transport and metabolism. We have begun to develop this model by utilizing sequence variants to study how polymorphic markers in two genes (SRD5A2 and AR) are related to prostate cancer risk within and between racial-ethnic groups. We are now collaborating with the Whitehead Institute/MIT, Center for Genome Research, to screen for single nucleotide polymorphisms in additional genes relevant to the androgen pathway and prostate cell growth. The model when fully developed can potentially provide a basis for targeting populations for screening interventions and for implementing primary preventive strategies.


  

Author Contacts

Brian E. Henderson, MD
USC/Norris Comprehensive Cancer Center
1441 Eastlake Ave., #4425
Los Angeles, CA 90033-0800 (USA)
Tel. +1 323 865 0419, Fax +1 323 865 0427, E-Mail behender@hsc.usc.edu

  

Article Information

Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 1, Number of References : 38

  

Publication Details

European Urology
Official Organ of the European Association of Urology

Vol. 35, No. 5-6, Year 1999 (Cover Date: May-June 1999)

Journal Editor: C.C. Schulman, Brussels
ISSN: 0302–2838 (Print), eISSN: 1421–993X (Online)

For additional information: http://www.karger.ch/journals/eur


Article / Publication Details

First-Page Preview
Abstract of Genetic and Environmental Factors in Prostate Cancer Genesis

Published online: 4/16/2012

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 0302-2838 (Print)
eISSN: 1421-993X (Online)

For additional information: http://www.karger.com/EUR


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.