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Table of Contents
Vol. 1, No. 4, 2009
Issue release date: June 2009
Section title: Research Article
J Innate Immun 2009;1:309–321
(DOI:10.1159/000200773)

Tube Is an IRAK-4 Homolog in a Toll Pathway Adapted for Development and Immunity

Towb P. · Sun H. · Wasserman S.A.
Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: 10/1/2008
Accepted: 11/4/2008
Published online: 2/10/2009
Issue release date: June 2009

Number of Print Pages: 13
Number of Figures: 6
Number of Tables: 2

ISSN: 1662-811X (Print)
eISSN: 1662-8128 (Online)

For additional information: http://www.karger.com/JIN

Abstract

Acting through the Pelle and IRAK family of protein kinases, Toll receptors mediate innate immune responses in animals ranging from insects to humans. In flies, the Toll pathway also functions in patterning of the syncytial embryo and requires Tube, a Drosophila-specific adaptor protein lacking a catalytic domain. Here we provide evidence that the Tube, Pelle, and IRAK proteins originated from a common ancestral gene. Following gene duplication, IRAK-4, Tube-like kinases, and Tube diverged from IRAK-1, Pelle, and related kinases. Remarkably, the function of Tube and Pelle in Drosophila embryos can be reconstituted in a chimera modeled on the predicted progenitor gene. In addition, a divergent property of downstream transcription factors was correlated with developmental function. Together, these studies reveal previously unrecognized parallels in Toll signaling in fly and human innate immunity and shed light on the evolution of pathway organization and function.

© 2009 S. Karger AG, Basel


  

Author Contacts

Dr. Steven A. Wasserman
Section of Cell and Developmental Biology, Division of Biological Sciences
University of California at San Diego, Bonner Hall, Room 4402, MC 0349
9500 Gilman Drive, La Jolla, CA 92093-0349 (USA)
Tel. +1 858 822 2408, Fax +1 858 822 3201, E-Mail stevenw@ucsd.edu

  

Article Information

Received: October 1, 2008
Accepted after revision: November 4, 2008
Published online: February 10, 2009
Number of Print Pages : 13
Number of Figures : 6, Number of Tables : 2, Number of References : 69

  

Publication Details

Journal of Innate Immunity

Vol. 1, No. 4, Year 2009 (Cover Date: April 2009)

Journal Editor: Herwald H. (Lund), Egesten A. (Lund)
ISSN: 1662-811X (Print), eISSN: 1662-8128 (Online)

For additional information: http://www.karger.com/JIN


Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: 10/1/2008
Accepted: 11/4/2008
Published online: 2/10/2009
Issue release date: June 2009

Number of Print Pages: 13
Number of Figures: 6
Number of Tables: 2

ISSN: 1662-811X (Print)
eISSN: 1662-8128 (Online)

For additional information: http://www.karger.com/JIN


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