Vagal Regulation of Gastric Function Involves Thyrotropin Releasing Hormone in the Medullary Raphe Nuclei and Dorsal Vagal ComplexTaché Y. · Yang H. · Yoneda M.
aCURE/UCLA Digestive Disease Center, VA Wadsworth Medical Center, Department of Medicine and Brain Research Institute, UCLA, Los Angeles, Calif., USA; bSecond Department of Medicine, Asahikawa Medical College, Asahikawa, Japan
There is convincing electrophysiological, neuroanatomical and functional data in support of an excitatory action of thyrotropin-releasing hormone (TRH) on the dorsal motor nucleus of the vagus neurons leading to stimulation of vagal outflow to the stomach and to a vagal cholinergic-dependent stimulation of gastric secretory and motor function and alterations of mucosal integrity in rats and cats. The raphe pallidus and obscurus have become important medullary nuclei regulating vagal function through their TRH and serotonin projections to the dorsal vagal complex. However, still little is known about the transmitters and conditions which influence the activity of these TRH-containing medullary raphe neurons. Existing knowledge points out a possible physiological role of TRH in mediating vagal reflex and the cephalic phase of digestion.
Yvette Taché, PhD, Bldg. 115, Room 203, VA Wadsworth Medical Center, Wilshire and Sawtelle Blvds., Los Angeles, CA 90073 (USA)
Received: February 1, 1993
Accepted: February 24, 1993
Published online: February 05, 2009
Number of Print Pages : 8
Digestion (International Journal of Gastroenterology)
Vol. 54, No. 2, Year 1993 (Cover Date: 1993)
Journal Editor: Beglinger C. (Basel), Göke B. (Munich)
ISSN: 0012-2823 (Print), eISSN: 1421-9867 (Online)
For additional information: http://www.karger.com/DIG