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Vol. 55, No. 4, 1994
Issue release date: 1994
Section title: Original Paper
Digestion 1994;55:221–228
(DOI:10.1159/000201151)

Secretion of Glucagon-Like Peptide-1 and Reactive Hypoglycemia after Partial Gastrectomy

Andreasen J.J.a · Ørskov C.b · Holst J.J.c
Departments of aSurgery C and bClinical Biochemistry, Rigshospitalet, and cDepartment of Medical Physiology, Panum Institute, University of Copenhagen, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/15/1993
Accepted: 12/16/1993
Published online: 2/5/2009
Issue release date: 1994

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Glucagon-like peptide-1 is a peptide hormone from the distal small intestine which stimulates insulin secretion and inhibits glucagon secretion and thereby lowers blood glucose. This hormone, therefore, could be involved in the pathogenesis of postprandial reactive hypoglycemia. We subjected 8 patients showing symptoms of early dumping after partial gastrectomy to an oral 100 g glucose load and measured blood glucose and plasma insulin, C-peptide, glucagon, enteroglucagon and GLP-1 concentrations for 3.5 h after ingestion. Ten matched controls were treated similarly. The patients had higher blood glucose concentrations for the initial 60 min, but lower values for the remaining test period with a nadir of 2.76 ± 0.19mmol/l at 146 ± 17 min after glucose (controls: 3.36 ± 0.21 mmol/l at 210 ± 9 min). GLP-1 and enteroglucagon responses were grossly elevated in patients compared to controls and insulin and C-peptide levels were higher during the initial 60 min. Glucagon concentrations increased in patients and decreased in controls. When hypoglycemia occurred, GLP-1 levels were only moderately elevated and insulin and C-peptide levels were lower and glucagon levels higher in patients than in controls. Thus, mechanisms other than release of GLP-1 seem to be responsible for the observed changes in the concentrations of glucose and glucoregulatory hormones.

© 1994 S. Karger AG, Basel


  

Author Contacts

J.J. Hoist, MD, Department of Medical Physiology, The Panum Institute, Blegdamsvej 3, DK-2200 Copenhagen N (Denmark)

  

Article Information

Received: December 15, 1993
Accepted: December 16, 1993
Published online: February 05, 2009
Number of Print Pages : 8

  

Publication Details

Digestion (International Journal of Gastroenterology)

Vol. 55, No. 4, Year 1994 (Cover Date: 1994)

Journal Editor: Beglinger C. (Basel), Göke B. (Munich)
ISSN: 0012-2823 (Print), eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/15/1993
Accepted: 12/16/1993
Published online: 2/5/2009
Issue release date: 1994

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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