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Vol. 30, No. 1, 2009
Issue release date: July 2009
Section title: Original Report: Patient-Oriented, Translational Research
Am J Nephrol 2009;30:55–63
(DOI:10.1159/000201416)

Prognostic Significance of Ankle-Brachial Index, Brachial-Ankle Pulse Wave Velocity, Flow-Mediated Dilation, and Nitroglycerin-Mediated Dilation in End-Stage Renal Disease

Morimoto S.a, b · Yurugi T.a · Aota Y.a · Sakuma T.a · Jo F.a · Nishikawa M.a · Iwasaka T.a · Maki K.b
aSecond Department of Internal Medicine, Kansai Medical University, Hirakata, and bDepartment of Internal Medicine, Omihachiman Community Medical Center, Omihachiman, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: 8/19/2008
Accepted: 12/20/2008
Published online: 2/10/2009
Issue release date: July 2009

Number of Print Pages: 9
Number of Figures: 7
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background: Identifying patients at high risk of cardiovascular disease is important in managing patients undergoing hemodialysis. Methods: We evaluated a series of prognostic values: flow-mediated dilation (FMD) and nitrogen-mediated dilation (NMD), an index of endothelium-dependent and endothelium-independent function, respectively, ankle-brachial index (ABI), and brachial-ankle pulse wave velocity (baPWV) in patients undergoing chronic hemodialysis. Results: A cohort of 199 patients was studied. At entry, these values were examined and the prognostic significances were investigated. In estimating the significance of baPWV, patients with ABI <0.9 were excluded. During the follow-up period, 24 deaths occurred including 14 cardiovascular and 10 noncardiovascular fatal events. Overall, the survival rates were significantly lower in the low ABI than in the high ABI group, but the survival rates were not significantly different between the high and low FMD, NMD, or baPWV groups. Cardiovascular survival rates were significantly lower in the low ABI than in the high ABI group, and in the high baPWV than in the low baPWV group. The survival rates were not significantly different between the high and low FMD or NMD groups. Conclusions: Screening hemodialysis patients by means of ABI and baPWV but not FMD or NMD provides complementary information in identifying a high-risk population in these patients.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: 8/19/2008
Accepted: 12/20/2008
Published online: 2/10/2009
Issue release date: July 2009

Number of Print Pages: 9
Number of Figures: 7
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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