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Vol. 22, No. 3, 2009
Issue release date: April 2009
Section title: Short Communication
Skin Pharmacol Physiol 2009;22:137–141
(DOI:10.1159/000201562)

Effects of Oral Epigallocatechin Gallate Supplementation on the Minimal Erythema Dose and UV-Induced Skin Damage

Jeon H.Y. · Kim J.K. · Kim W.G. · Lee S.J.
Food Research Institute, Amorepacific Corporation R&D Center, Yongin, Korea

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: 7/14/2008
Accepted: 12/11/2008
Published online: 2/12/2009

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Background/Aims: Excessive exposure to UV radiation causes acute adverse effects like sunburn and photosensitivity reactions and is involved in the induction and development of skin cancer. It has been reported that antioxidants have photoprotective effects against solar UV radiation. We investigated the effect of oral epigallocatechin gallate (EGCG), a powerful antioxidant in green tea, on the minimal erythema dose (MED) and UV-induced skin damage. Method: Female HWY/Slc hairless rats were fed the normal diet supplemented with 1,500 ppm EGCG for 8 weeks; then, the MED was determined and visual scores and transepidermal water loss were assessed to evaluate the severity of UV-induced skin damage. Results: At week 8 of the study, the use of dietary EGCG significantly increased MED. UV-radiation-induced sunburn severity and alterations in epidermal barrier function were also attenuated by the supplementation of EGCG. Conclusion: Regular intake of EGCG strengthens the skin’s tolerance by increasing MED and thus prevents UV-induced perturbation of epidermal barrier function and skin damage. These results suggest that EGCG is a potent candidate for systemic photoprotection.


  

Author Contacts

Sang Jun Lee, PhD
Food Research Institute, Amorepacific Corporation R&D Center
314-1, Bora-dong, Giheung-gu
Yongin-si, Gyeonggi-do 446-729 (Korea)
Tel. +82 31 280 5810, Fax +82 31 281 8392, E-Mail leesjun@amorepacific.com

  

Article Information

Received: July 14, 2008
Accepted after revision: December 11, 2008
Published online: February 12, 2009
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 0, Number of References : 17

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 22, No. 3, Year 2009 (Cover Date: April 2009)

Journal Editor: Lademann J. (Berlin)
ISSN: 1660-5527 (Print), eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: 7/14/2008
Accepted: 12/11/2008
Published online: 2/12/2009

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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