Journal Mobile Options
Table of Contents
Vol. 30, No. 1, 2009
Issue release date: July 2009
Section title: Original Report: Patient-Oriented, Translational Research
Am J Nephrol 2009;30:64–72
(DOI:10.1159/000202632)

25-Hydroxyvitamin D Deficiency and Inflammation and Their Association with Hemoglobin Levels in Chronic Kidney Disease

Kendrick J.a · Targher G.b · Smits G.a · Chonchol M.a
aDivision of Renal Diseases and Hypertension, University of Colorado Denver Health Sciences Center, Denver, Colo., USA; bSection of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: 10/17/2008
Accepted: 1/6/2009
Published online: 2/13/2009
Issue release date: July 2009

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background/Aims: There is limited information about the association of anemia with 25-hydroxyvitamin D [25(OH)D] deficiency and inflammation in the setting of decreased kidney function in the general population. Methods: We examined the association that anemia has with 25(OH)D deficiency and inflammation among 16,301 participants in the Third National Health and Nutrition Examination Survey (NHANES III). Measures of kidney function were estimated glomerular filtration rate (GFR) by using the Modification of Diet in Renal Disease equation. Results: The age-adjusted prevalence of anemia (hemoglobin <12 g/dl) at an estimated GFR of 59–30 ml/min/1.73 m2 was 17% increasing to 56% for those participants with an estimated GFR <30 ml/min/1.73 m2, while the age-adjusted prevalence of elevated C-reactive protein (CRP >0.21 mg/dl) and reduced 25(OH)D (<20 ng/ml) was 50 and 30%, respectively. After adjusting for demographics, comorbidities and laboratory results, 25(OH)D <20 ng/ml (OR: 1.17; 95% CI: 1.03–1.32; p = 0.014) and log CRP (OR: 3.63; 95% CI: 2.4–5.48 per unit increase of log CRP; p < 0.0001) were associated with hemoglobin levels <12 g/dl. Conclusion: This study provides evidence that lower 25(OH)D and higher CRP levels are independently associated with lower hemoglobin concentrations in kidney disease subjects not requiring dialysis.

© 2009 S. Karger AG, Basel


  

Author Contacts

Michel Chonchol, MD
University of Colorado Denver Health Sciences Center
Division of Renal Diseases and Hypertension, Box C-280
Denver, CO 80262 (USA)
Tel. +1 303 399 6997, Fax +1 303 399 3131, E-Mail Michel.Chonchol@uchsc.edu

  

Article Information

Received: October 17, 2008
Accepted: January 6, 2009
Published online: February 13, 2009
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 2, Number of References : 46

  

Publication Details

American Journal of Nephrology

Vol. 30, No. 1, Year 2009 (Cover Date: July 2009)

Journal Editor: Bakris G. (Chicago, Ill.)
ISSN: 0250-8095 (Print), eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: 10/17/2008
Accepted: 1/6/2009
Published online: 2/13/2009
Issue release date: July 2009

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.