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Vol. 27, No. 2, 2009
Issue release date: March 2009
Section title: Original Research Article
Dement Geriatr Cogn Disord 2009;27:194–200
(DOI:10.1159/000203130)

Biomarkers in Relation to Cognitive Reserve in Patients with Mild Cognitive Impairment – Proof of Concept

Rolstad S. · Nordlund A. · Eckerström C. · Gustavsson M.H. · Zetterberg H. · Wallin A.
Institute of Neuroscience and Physiology, Sahlgrenska Academy at Göteborg University, Mölndal, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 12/19/2008
Published online: 2/19/2009
Issue release date: March 2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background: The concept of the cognitive reserve (CR) posits that factors such as education enable compensation for the effect of brain pathology. Consequently, pathology should be more pronounced in individuals with higher CR before becoming clinically apparent. Biomarkers such as total tau (t-tau) and β-amyloid 42 (Aβ42) may be surrogates for pathology in relation to CR in patients with neurodegenerative disease. Objective: To examine the applicability of biomarkers as surrogates for pathology in relation to the CR in patients with mild cognitive impairment (MCI) either converting to dementia or remaining stable at follow-up. Method: Comparisons of baseline t-tau, Aβ42, educational years and global cognition for MCI patients either converting to dementia (n = 57) or remaining stable (n = 91) were made. Patients converting to dementia were grouped on the basis of educational level and compared considering biomarkers and neuropsychological tests. Results: Stable MCI patients were better educated, performed better cognitively, had higher Aβ42 levels and lower levels of t-tau. Converting MCI patients with higher education had lower levels of Aβ42 and performed equally in neuropsychological tests compared to those with lower education. Conclusion: Our results suggest that highly educated MCI patients subsequently converting to dementia display more amyloid pathology.

© 2009 S. Karger AG, Basel


  

Author Contacts

Sindre Rolstad
Institute of Neuroscience and Physiology
Wallinsgatan 6, Plan 4B
SE–431 31 Mölndal (Sweden)
Tel. +46 31 343 8687, Fax +46 31 776 9055, E-Mail sindre.rolstad@neuro.gu.se

  

Article Information

Accepted: December 19, 2008
Published online: February 19, 2009
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 4, Number of References : 41

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 27, No. 2, Year 2009 (Cover Date: March 2009)

Journal Editor: Chan-Palay V. (New York, N.Y.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: 12/19/2008
Published online: 2/19/2009
Issue release date: March 2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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