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Vol. 1, No. 3, 2009
Issue release date: April 2009
Section title: Review
J Innate Immun 2009;1:176–180
(DOI:10.1159/000203699)

Neutrophil Extracellular Traps: A Strategic Tactic to Defeat Pathogens with Potential Consequences for the Host

Medina E.
Infection Immunology Research Group, Department of Microbial Pathogenesis, HZI – Helmholtz Center for Infection Research, Braunschweig, Germany

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 10/3/2008
Accepted: 10/16/2008
Published online: 2/20/2009
Issue release date: April 2009

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1662-811X (Print)
eISSN: 1662-8128 (Online)

For additional information: http://www.karger.com/JIN

Abstract

Recent investigations have highlighted new roles for neutrophils in the biology of infection and inflammation. Neutrophils are one of the main players in the innate immune system and actively contribute to host defense by killing pathogens. Added to their ability to eliminate microorganisms by phagocytosis, neutrophils can also kill microbes by capturing them in extracellular structures consisting of granule proteins and DNA called neutrophil extracellular traps (NETs). This review summarizes the recent advancements regarding the structure, production and biological relevance of NETs.

© 2009 S. Karger AG, Basel


  

Author Contacts

Dr. Eva Medina
Infection Immunology Research Group, Department of Microbial Pathogenesis
Helmholtz Center for Infection Research
Inhoffenstrasse 7, DE–38124 Braunschweig (Germany)
Tel. +49 531 6181 4500, Fax +49 531 6181 4499, E-Mail eva.medina@helmholtz-hzi.de

  

Article Information

Received: October 3, 2008
Accepted after revision: October 16, 2008
Published online: February 20, 2009
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 0, Number of References : 26

  

Publication Details

Journal of Innate Immunity

Vol. 1, No. 3, Year 2009 (Cover Date: April 2009)

Journal Editor: Herwald H. (Lund), Egesten A. (Lund)
ISSN: 1662-811X (Print), eISSN: 1662-8128 (Online)

For additional information: http://www.karger.com/JIN


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 10/3/2008
Accepted: 10/16/2008
Published online: 2/20/2009
Issue release date: April 2009

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1662-811X (Print)
eISSN: 1662-8128 (Online)

For additional information: http://www.karger.com/JIN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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