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Vol. 92, No. 3, 1994
Issue release date: 1994
Acta Haematol 1994;92:157–159
Case Report

Multiple Cranial Neuritis Associated with Large Granular Lymphocytosis

Kono I.a · Takashima T.b · Tsuda S.b · Ueda Y.a · Ijichi T.a · Fujita N.c · Araki K.b · Nakajima K.a
aDepartment of Neurology and Gerontology, Research Institute for Neurological Disease and Geriatrics, bThird Department of Internal Medicine, and cDepartment of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Japan


A patient with a unique form of large granular lymphocytosis and multiple cranial neuritis is reported. The patient presented with facial weakness, diplopia and dysarthria. An increase in large granular lymphocytes (LGLs) was seen in blood (1.8 × 109/1), CSF (237/μl) and bone marrow (20% in a normocellular bone marrow). The phenotype of the LGLs in CSF, blood and bone marrow was CD2+ CD3+ CD4+ CD8- CD16- CD56- and CD57-. The unique features of this case include the CD4+ phenotype, the relative abundance of CSF LGL and the clinical presentation.

 goto top of outline Author Contacts

Ichiyo Kono, MD, Department of Neurology and Gerontology, Research Institute for Neurological Disease and Geriatrics, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602 (Japan)

 goto top of outline Article Information

Received: March 14, 1994
Accepted: September 22, 1994
Published online: February 18, 2009
Number of Print Pages : 3

 goto top of outline Publication Details

Acta Haematologica

Vol. 92, No. 3, Year 1994 (Cover Date: 1994)

Journal Editor: Ben-Bassat I. (Qiryat-Ono)
ISSN: 0001-5792 (Print), eISSN: 1421-9662 (Online)

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