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Table of Contents
Vol. 90, No. 1, 1993
Issue release date: 1993
Section title: Original Paper
Acta Haematol 1993;90:8–12
(DOI:10.1159/000204365)

Retrospective Study on the Influence of Human Parvovirus B19 Infection among Children with Malignant Diseases

Yoto Y.a · Kudoh T.a · Suzuki N.a · Matsunaga Y.b · Chiba S.a
aDepartment of Pediatrics, School of Medicine, Sapporo Medical University, Sapporo, bNational Institute of Health, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 25, 1993
Accepted: May 12, 1993
Published online: February 18, 2009
Issue release date: 1993

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Human parvovirus B19 (B19) is a known cause of erythema infectiosum (fifth disease) and aplastic crisis in patients with hemolytic anemias. When patients with malignant diseases are infected by B19 during chemotherapy, erythroid suppression of bone marrow sometimes occurs. We performed a retrospective investigation of B19 infection among 95 children with malignant diseases in our hospital during the past 14 years. By the method of dot blot hybridization, 9 of 95 patients were found to be positive for B19 DNA during chemotherapy. All 9 patients had reticulocytopenia at the time B19 DNA was detected in their serum samples. Neutropenia and thrombocytopenia were not found. Seven of them had only transient reticulocytopenia. Serum samples from 2 other patients were positive for B19 DNA for a longer time. They suffered from persistent anemia for about 2 and 13 month, respectively. The years when B19 DNA was detected from the 9 patients corresponded to the prevalence of erythema infectiosum in Japan.

© 1993 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 25, 1993
Accepted: May 12, 1993
Published online: February 18, 2009
Issue release date: 1993

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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