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Case Report

Thromboembolic Complications in Beta Thalassemia major

Michaeli J.a · Mittelman M.b · Grisaru D.a · Rachmilewitz E.A.a

Author affiliations

aDepartment of Hematology, Hadassah University Hospital, Jerusalem, bDepartment of Medicine B, Hasharon Hospital, Petah-Tikva, Israel

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Acta Haematol 1992;87:71–74

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: December 03, 1990
Accepted: July 03, 1991
Published online: February 19, 2009
Issue release date: 1992

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Thromboembolic complications in β-thalassemia major have seldom been reported and their association with risk factors such as left ventricular failure and postsplenectomy thrombocytosis has remained speculative. In this report we describe 4 patients with unusual thromboembolic manifestations: recurrent arterial occlusion, recurrent pulmonary thromboembolism, venous thrombosis and a fatal cerebrovascular event. Although in all patients both risk factors were present, the precise causes for their thromboembolic complications were not identified. In 1 patient, however, a marked increase in hematocrit following blood transfusion resulted, in all likelihood, in a fatal cerebrovascular infarction. We suspect that these patients (constituting 4% of our β-thalassemic group) represent a subset of those with high susceptibility to both arterial and venous thromboembolic complications.

© 1992 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: December 03, 1990
Accepted: July 03, 1991
Published online: February 19, 2009
Issue release date: 1992

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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