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Table of Contents
Vol. 86, No. 4, 1991
Issue release date: 1991
Section title: Original Paper
Acta Haematol 1991;86:183–188
(DOI:10.1159/000204831)

Changes in CuZn-Superoxide Dismutase Gene during Induced Erythroid and Myeloid Differentiation

Tomoda T.a · Nomura I.a · Kurashige T.a · Kubonishi I.b · Miyoshi I.b · Sukenaga Y.d · Taniguchi T.c
aDepartment of Pediatrics, bDepartment of Medicine, and cMedical Research Laboratory, Kochi Medical School, Kochi, and dResearch Laboratories, Pharmaceuticals Group, Nippon Kayaku Co., Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 29, 1990
Accepted: April 16, 1991
Published online: February 19, 2009
Issue release date: 1991

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

We investigated the alteration of CuZn-superoxide dismutase during erythroid and myeloid differentiation in order to elucidate its physiological significance in different types of cells. We measured enzyme activity and mRNA levels of superoxide dismutase in the process of differentiation to erythroid cells or myeloid cells. When human leukemia K562 cells are incubated in the presence of 80 μM hemin, benzidine-positive cells appear on day 1 and 80% of the cells become positive on day 5. During hemin-induced erythroid differentiation, CuZn-superoxide dismutase activity increases 3.5-fold of the initial value and mRNA for CuZn-superoxide dismutase increases prior to the activity to the same extent. On the other hand, when human pro-myelocytic leukemia HL-60 cells are incubated in the presence of 1.3% dimethyl sulfoxide, nitroblue tetrazoli-um-positive cells reach approximately 90% on day 5. During dimethyl sulfoxide-induced myeloid differentiation, the activity of CuZn-superoxide dismutase decreases below 15% of the initial value on day 5 and mRNA for CuZn-superoxide dismutase decreases as well. The results indicate that the synthesis of superoxide dismutase is linked with either the erythroid or myeloid differentiation program.

© 1991 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 29, 1990
Accepted: April 16, 1991
Published online: February 19, 2009
Issue release date: 1991

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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