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Table of Contents
Vol. 54, No. 1, 2009
Issue release date: March 2009
Section title: Original Paper
Ann Nutr Metab 2009;54:43–51
(DOI:10.1159/000205319)

A Nutrigenomic Inflammation-Related PBMC-Based Approach to Predict the Weight-Loss Regain in Obese Subjects

Goyenechea E. · Parra D. · Crujeiras A.B. · Abete I. · Martínez J.A.
Department of Nutrition and Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 17, 2008
Accepted: November 21, 2008
Published online: February 27, 2009
Issue release date: March 2009

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background: Long-term maintenance of a dietary-induced weight loss continues to be a major health problem and warrants research on innovative approaches to understand weight stability. We investigated the role of the proinflammatory status on weight changes in obese subjects receiving a low-calorie diet (LCD) and during the subsequent 6-month weight maintenance period. Methods: Eighty-four subjects (age: 34.2 ± 0.53 years; body mass index, BMI: 30.4 ± 1.8 kg/m2) followed an 8-week LCD intervention and were contacted again 6 months later. Body composition, circulating proinflammatory markers [tumor necrosis factor (TNF)α, interleukin-6, C-reactive protein and leptin] and mRNA levels of inflammation-related genes [TNFα and nuclear factor (NF) κBtranscription subunits] in peripheral blood mononuclear cells (PBMC) were evaluated. Results: The 6-month weight regain was predicted by high concentrations of TNFα at LCD completion (OR = 4.21, p = 0.036) along with the baseline amount of fat mass (OR = 7.23, p = 0.029). In addition, baseline leptin concentrations (p = 0.028) as well as mRNA levels of TNFα and NFκB subunits were higher at the end of the dietary intervention (p < 0.05) in PBMC of subjects who regained ≥10% of the dietary-induced weight loss. Conclusions: These findings demonstrate a role for the proinflammatory state and body adiposity in the prediction of weight-loss regain. This relationship could contribute to the design of more personalized nutritional treatments in obese patients and favor the weight maintenance process.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 17, 2008
Accepted: November 21, 2008
Published online: February 27, 2009
Issue release date: March 2009

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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