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Original Paper

Nitric Oxide as an Upstream Signal of p38 Mediates Hypoxia/Reoxygenation-Induced Neuronal Death

Chen M.a · Sun H.-Y.b · Li S.-J.a · Das M.a · Kong J.-M.a, c · Gao T.-M.a

Author affiliations

Departments of aAnatomy and Neurobiology, bPhysiology, Southern Medical University, Guangzhou, China; cDepartment of Human Anatomy and Cell Science, University of Manitoba, Faculty of Medicine, Winnipeg, Man., Canada

Corresponding Author

Tian-Ming Gao, MD, PhD

Department of Anatomy and Neurobiology

Southern Medical University

Guangzhou 510515 (China)

Tel./Fax +86 20 6164 8216, E-Mail tgao@fimmu.com

Related Articles for ""

Neurosignals 2009;17:162–168

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Abstract

Nitric oxide (NO) and p38 have been shown to be involved in the ischemia/hypoxia-induced neuronal injury. In this study, we examined the activation patterns of mitogen-activated protein kinases and explored the relationship between NO and p38 in a model of hippocampal neuronal death induced by hypoxia/reoxygenation (H/R). p38 activity increased robustly during hypoxia and after reoxygenation, while the increase of c-Jun amino-terminal kinase and extracellular signal-related kinase activities showed mild tendency. Inhibition of p38 with SB203580 or SB202190 rescued neuronal death, whereas inhibition of extracellular signal-related kinases with PD98059 or c-Jun amino-terminal kinases with SP600125 offered no protection. p38 inhibitors also reduced neuronal death induced by the NO donor S-nitrosoglutathione. L-NAME, a nonspecific NO synthase inhibitor, blocked the p38 activation and rescued H/R-induced neuronal death. These results suggest that NO is an upstream signal of p38 that mediates the H/R-induced neuronal death.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 22, 2008
Accepted: June 24, 2008
Published online: March 04, 2009
Issue release date: May 2009

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: http://www.karger.com/NSG


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