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Vol. 27, No. 4, 2009
Issue release date: April 2009
Section title: Original Paper
Cerebrovasc Dis 2009;27:375–383
(DOI:10.1159/000207441)

Is Antioxidant and n–3 Supplementation Able to Improve Functional Status in Poststroke Patients? Results from the Nutristroke Trial

Garbagnati F. · Cairella G. · De Martino A. · Multari M. · Scognamiglio U. · Venturiero V. · Paolucci S.
aCentro Studi Alimentazione e Riabilitazione, IRCCS Fondazione S. Lucia, bDepartment of Biology, University of Rome Tor Vergata, and cIRCCS Fondazione S. Lucia, Rome, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/10/2008
Accepted: 11/25/2008
Published online: 3/10/2009

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 6

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: To test whether supplementary antioxidants and n–3 fatty acids, alone or in combination, could improve functional status in stroke survivors. Methods: We performed a randomized, double-blind, placebo-controlled clinical trial in 72 stroke patients (47 males; age 65.3 ± 12.9 years) admitted to a rehabilitation hospital for sequelae of first-ever ischemic stroke, and divided them into 4 subgroups. Group 1 patients received daily oral antioxidants, group 2 received n–3 polyunsaturated fatty acids, group 3 both supplements, and group 4 placebo, all for 12 months. No difference at baseline was observed among groups in neurological severity or in disability. All measures were repeated after 6 and 12 months of treatment. All major clinical events were recorded. Results: At baseline, 25% of the patients had a low plasma vitamin status, and 48.5% was at risk of undernutrition. At the 1-year follow-up, we observed a trend for lower mortality (p = 0.060) in subgroups treated with n–3 fatty acids, but without significant differences in rehabilitation result status among groups. Conclusions: Malnutrition is widely observed in patients admitted to a rehabilitative hospital for stroke rehabilitation, and dietary supplementation, even if not able to improve rehabilitation results, is likely to reduce mortality at the 1-year follow-up.


  

Author Contacts

F. Garbagnati
CeSAR – Centro Studi Alimentazione e Riabilitazione
c/o Fondazione S. Lucia, Via Ardeatina, 306
IT–00179 Roma (Italy)
Tel. +39 06 5150 1541, Fax +39 06 5032 097, E-Mail cesar@hsantalucia.it

  

Article Information

Received: July 10, 2008
Accepted after revision: November 25, 2008
Published online: March 10, 2009
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 6, Number of References : 46

  

Publication Details

Cerebrovascular Diseases

Vol. 27, No. 4, Year 2009 (Cover Date: April 2009)

Journal Editor: Hennerici M.G. (Mannheim)
ISSN: 1015-9770 (Print), eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/10/2008
Accepted: 11/25/2008
Published online: 3/10/2009

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 6

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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