Longitudinal Cognitive Decline in Subcortical Ischemic Vascular Disease – The LADIS StudyJokinen H. · Kalska H. · Ylikoski R. · Madureira S. · Verdelho A. · van der Flier W.M. · Scheltens P. · Barkhof F. · Visser M.C. · Fazekas F. · Schmidt R. · O’Brien J. · Waldemar G. · Wallin A. · Chabriat H. · Pantoni L. · Inzitari D. · Erkinjuntti T.
aDepartment of Psychology and the bMemory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland; cServiço de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisbon, Portugal; dDepartment of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands; eDepartment of Neurology and MRI Institute, Medical University Graz, Graz, Austria; fInstitute for Ageing and Health, University of Newcastle, Newcastle-upon-Tyne, UK; gMemory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark; hInstitute of Clinical Neuroscience, Goteborg University, Gothenburg, Sweden; iDepartment of Neurology, Hôpital Lariboisière, Paris, France; jDepartment of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
Background: Cross-sectional studies have indicated that subcortical ischemic vascular disease (SIVD), as defined according to imaging criteria, is associated with a specific clinical and cognitive profile. Much less is known about the long-term cognitive consequences of SIVD. The aim of the study was to investigate the longitudinal cognitive performance and incident dementia in subjects with and without SIVD in a sample of older adults with white matter lesions. Methods: In the Leukoaraiosis and Disability (LADIS) study, 639 participants were examined with annual clinical and neuropsychological evaluations for 3 years. The subjects meeting the MRI criteria of SIVD at baseline were compared to the other subjects of the sample with linear mixed models. Results: The overall level of cognitive performance over the follow-up period was inferior in multiple cognitive domains in SIVD subjects as compared to the reference group. The subjects with SIVD presented significantly steeper decline of performance in the Stroop test (parts I and II), Trail Making A test, Verbal fluency test, and Mini-Mental State Examination. They also had a threefold risk of developing dementia during follow-up independently of age, sex, education and medial temporal lobe atrophy. Conclusions: SIVD, as a manifestation of cerebral small vessel disease, is related to progressive cognitive impairment and a considerable risk of developing dementia. SIVD seems to specifically contribute to the deterioration of psychomotor speed, executive control, and global cognitive function.
Hanna Jokinen, PhD
Department of Neurology, Helsinki University Central Hospital
PO Box 302, FI–00029 HUS, Helsinki (Finland)
Tel. +358 40 594 2286, Fax +358 9 4717 4088
Received: June 17, 2008
Accepted: December 15, 2008
Published online: March 10, 2009
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 1, Number of References : 38
Vol. 27, No. 4, Year 2009 (Cover Date: April 2009)
Journal Editor: Hennerici M.G. (Mannheim)
ISSN: 1015-9770 (Print), eISSN: 1421-9786 (Online)
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