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Vol. 42, No. 3, 2009
Issue release date: April 2009
Section title: Original Paper
Psychopathology 2009;42:148–156
(DOI:10.1159/000207456)

Influence of Clinical and Neuropsychological Variables on the Psychosocial and Occupational Outcome of Remitted Bipolar Patients

Mur M.a · Portella M.J.b · Martinez-Aran A.c · Pifarre J.a · Vieta E.c
aMental Health Service, Santa Maria Hospital, IRBLleida (Institute for Research in Biomedicine), University of Lleida, Lleida, bPsychiatry Service, Research Institute, Hospital de la Santa Creu i Sant Pau, CIBER-SAM, Universitat Autònoma de Barcelona, and cClinical Institute of Neuroscience, Hospital Clinic of Barcelona, IDIBAPS, CIBER-SAM, University of Barcelona, Barcelona, Spain

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/21/2008
Accepted: 7/23/2008
Published online: 3/10/2009
Issue release date: April 2009

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 3

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: http://www.karger.com/PSP

Abstract

Objective: To measure the impact of the clinical course, the residual mood symptoms and the cognitive variables on the psychosocial and occupational functioning in bipolar disorder patients in remission. Method: Forty-four euthymic DSM-IV-TR bipolar lithium-treated outpatients were assessed with a clinical interview and neuropsychological testing. To assess psychosocial function, some psychometric scales were administered (Global Assessment of Functioning Scale and World Health Organization Disability Assessment Schedule), and to evaluate occupational function, the sample was divided according to the current work status (active vs. inactive). Cognitive assessment was performed by means of a neuropsychological test battery tapping into the main cognitive domains (executive function, attention, processing speed, verbal memory and visual memory). Results: Measures of psychosocial functioning were significantly correlated with cognition (processing speed, p = 0.004), clinical severity (p = 0.03) and residual depressive symptoms (p = 0.05). Occupational functioning showed a significant effect with a cognitive domain (visual memory, p = 0.006) and a clinical variable (chronicity, p = 0.04) but not with residual mood symptoms (p > 0.2). Conclusions: Remission in bipolar disorder is not synonymous with recovering in psychosocial and occupational functioning. Cognitive deficits, clinical course and persistent subsyndromal symptoms may compromise psychosocial functioning, and neurocognitive symptoms and chronicity may particularly affect occupational functioning.

© 2009 S. Karger AG, Basel


  

Article Information

Received: April 21, 2008
Accepted after revision: July 23, 2008
Published online: March 10, 2009
Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 3, Number of References : 79

  

Publication Details

Psychopathology (International Journal of Descriptive and Experimental Psychopathology, Phenomenology and Psychiatric Diagnosis)

Vol. 42, No. 3, Year 2009 (Cover Date: April 2009)

Journal Editor: Mundt C. (Heidelberg), Akiskal H.S. (San Diego, Calif.), Mezzich J.E. (New York, N.Y.)
ISSN: 0254-4962 (Print), eISSN: 1423-033X (Online)

For additional information: http://www.karger.com/PSP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/21/2008
Accepted: 7/23/2008
Published online: 3/10/2009
Issue release date: April 2009

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 3

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: http://www.karger.com/PSP


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