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Vol. 31, No. 1-2, 2009
Issue release date: April 2009
Section title: Review
Dev Neurosci 2009;31:36–49
(DOI:10.1159/000207492)

Towards Conceptualizing a Neural Systems-Based Anatomy of Attention-Deficit/Hyperactivity Disorder

Makris N. · Biederman J. · Monuteaux M.C. · Seidman L.J.
aHarvard Medical School Department of Psychiatry and bCenter for Morphometric Analysis, Harvard Medical School Department of Neurology, Massachusetts General Hospital, cDepartment of Anatomy and Neurobiology, Boston University School of Medicine, and dPublic Psychiatry Division of the Beth Israel Deaconess Medical Center,Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 3/25/2008
Accepted: 7/22/2008
Published online: 4/17/2009

Number of Print Pages: 14
Number of Figures: 4
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

Convergent data from neuroimaging, neuropsychological, genetic and neurochemical studies in attention-deficit/hyperactivity disorder (ADHD) have implicated dysfunction of the dorsolateral prefrontal cortex (DLPFC) and dorsal anterior cingulate cortex (dACC), which form the cortical arm of the frontostriatal network supporting executive functions. Furthermore, besides the DLPFC and dACC, structural and functional imaging studies have shown abnormalities in key brain regions within distributed cortical networks supporting attention. The conceptualization of neural systems biology in ADHD aims at the understanding of what organizing principles have been altered during development within the brain of a person with ADHD.Characterizing these neural systems using neuroimaging could be critical for the description of structural endophenotypes, and may provide the capability of in vivo categorization and correlation with behavior and genes.


  

Author Contacts

Nikos Makris, MD, PhD
Center for Morphometric Analysis, Massachusetts General Hospital
149 13th Street
Charlestown, MA 02129 (USA)
Tel. +1 617 726 5733, Fax +1 617 726 5677, E-Mail nikos@cma.mgh.harvard.edu

  

Article Information

Received: March 25, 2008
Accepted after revision: September 11, 2008
Published online: April 17, 2009
Number of Print Pages : 14
Number of Figures : 4, Number of Tables : 0, Number of References : 175

  

Publication Details

Developmental Neuroscience

Vol. 31, No. 1-2, Year 2009 (Cover Date: April 2009)

Journal Editor: Levison S.W. (Newark, N.J.)
ISSN: 0378-5866 (Print), eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 3/25/2008
Accepted: 7/22/2008
Published online: 4/17/2009

Number of Print Pages: 14
Number of Figures: 4
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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