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Vol. 124, No. 2, 2009
Issue release date: May 2009
Section title: Original Article
Cytogenet Genome Res 2009;124:128–131
(DOI:10.1159/000207517)

Interstitial telomeric sequences (ITSs) are not located at the exact evolutionary breakpoints in primates

Farré M. · Ponsà M. · Bosch M.
aDepartament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, bGenètica de la Conservació Animal, IRTA, Cabrils (Spain)

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: 12/4/2008
Published online: 5/5/2009

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Although their function has not yet been clearly elucidated, interstitial telomeric sequences (ITSs) have been cytogenetically associated with chromosomal reorganizations, fragile sites, and recombination hotspots. In this paper, we show that ITSs are not located at the exact evolutionary breakpoints of the inversions between human and chimpanzee and between human and rhesus macaque chromosomes. We proved that ITSs are not signs of repair in the breakpoints of the chromosome reorganizations analyzed. We found ITSs in the region (0.7–2.7 Mb) flanking one of the two breakpoints in all the inversions assessed. The presence of ITSs in those locations is not by chance. They are short (up to 7.83 repeats) and almost perfect (82.5–97.1% matches). The ITSs are conserved in the species compared, showing that they were present before the reorganizations occurred.


  

Author Contacts

Montserrat Ponsà
Unitat de Biologia Cellular, Departament de Biologia Cellular
Fisiologia i Immunologia, Universitat Autònoma de Barcelona
Facultat de Biociències, Campus UAB, ES–08193 Cerdanyola del Vallès (Spain)
telephone: +34 93 581 2781; fax: +34 93 581 2295; e-mail: montse.ponsa@uab.es

  

Article Information

This work was supported by Ministerio de Educación y Ciencia MEC project (BFU2004-03422/BMC). M. Farré was supported by a grant from the Universitat Autònoma de Barcelona.

Accepted after revision: December 4, 2008 by M. Schmid
Published online: May 05, 2009
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 1, Number of References : 21

  

Publication Details

Cytogenetic and Genome Research

Vol. 124, No. 2, Year 2009 (Cover Date: May 2009)

Journal Editor: Schmid M. (Würzburg)
ISSN: 1424-8581 (Print), eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: 12/4/2008
Published online: 5/5/2009

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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